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Antimicrobial susceptibility of Bacillus anthracis
1Section of Infectious Diseases, Faculty of Medicine, Erciyes University, Kayseri, Turkey.
Scandinavian Journal of Infectious Diseases
|January 1, 1991
Summary
Bacillus anthracis isolates showed sensitivity to penicillins and fluoroquinolones like ciprofloxacin. However, resistance was observed against several cephalosporins, indicating varying antimicrobial susceptibility in these bacterial strains.
Area of Science:
- Microbiology
- Infectious Diseases
- Antimicrobial Resistance
Background:
- Bacillus anthracis is the causative agent of anthrax, a serious infectious disease.
- Understanding antimicrobial susceptibility patterns is crucial for effective treatment and control of anthrax.
Purpose of the Study:
- To evaluate the susceptibility of Bacillus anthracis isolates to a range of antimicrobial agents.
- To identify potential resistance mechanisms and effective treatment options.
Main Methods:
- Agar dilution method was employed to test 22 Bacillus anthracis isolates.
- Susceptibility testing was performed against 27 different antimicrobial agents.
Main Results:
- All isolates were sensitive to penicillins and did not produce beta-lactamase.
- While sensitive to some cephalosporins (cefazolin, cephalothin, cephradine, cefoperazone), significant resistance was noted for others (cefuroxime, cefotaxime, ceftizoxime, ceftriaxone, ceftazidime).
- Ofloxacin and ciprofloxacin demonstrated excellent activity against all isolates.
Conclusions:
- Penicillins remain a reliable treatment option for Bacillus anthracis infections.
- Emerging resistance to certain cephalosporins warrants careful consideration in treatment selection.
- Fluoroquinolones, including ofloxacin and ciprofloxacin, are highly effective against Bacillus anthracis.