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Design of cell-surface-retained polymers for artificial ligand display

Ryosuke Kamitani1, Kenichi Niikura, Takaharu Okajima

  • 1Division of Chemistry, Graduate School of Science, Hokkaido University, Kita21, Nishi10, Kita-Ku, Sapporo 001-0021, Japan.

Chembiochem : a European Journal of Chemical Biology
|December 19, 2008
PubMed
Summary

No abstract available in PubMed .

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Proteins are dynamic macromolecules that carry out a wide variety of essential processes; however, the activities of most proteins depend on their interactions with other molecules or ions, known as ligands.
Protein-ligand interactions are quite specific; even though numerous potential ligands surround a cellular protein at any given time, only a particular ligand can bind to that protein. Moreover, a ligand binds only to a dedicated area on the surface of the protein, known as the...