Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Nociception

Nociception

Nociception—the ability to feel pain—is essential for an organism’s survival and overall well-being. Noxious stimuli such as piercing pain from a sharp object, heat from an open flame, or contact with corrosive chemicals are first detected by sensory receptors, called nociceptors, located on nerve endings. Nociceptors express ion channels that convert noxious stimuli into electrical signals. When these signals reach the brain via sensory neurons, they are perceived as pain. Thus, pain helps the...

Acute Inflammation I: Inflammatory Response

Acute Inflammation I: Inflammatory Response

Acute inflammation is a rapid, short-lived physiological response to tissue injury or infection, designed to eliminate harmful agents and initiate repair. This tightly regulated process typically lasts from minutes to several days and is triggered by factors such as microbial invasion, physical trauma, or chemical injury.Recognition and Mediator ReleaseThe inflammatory response begins when resident immune cells—such as mast cells, macrophages, and dendritic cells—detect damage-associated...

Acute Inflammation III: Local and Systemic Effects

Acute Inflammation III: Local and Systemic Effects

Acute inflammation produces a coordinated set of local and systemic changes that limit injury, eliminate pathogens, and initiate repair. These responses arise within minutes of infection, trauma, or chemical insult and are driven by vascular alterations and leukocyte-derived mediators. When the stimulus resolves, the reaction typically abates within days.Local EffectsAt the site of injury, arteriolar vasodilation increases blood flow, resulting in redness and warmth. Simultaneously, increased...

Inflammation

Inflammation

Cells of the Innate Immune Response

Cells of the Innate Immune Response

The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...

Acute Inflammation II: Cellular Phase

Acute Inflammation II: Cellular Phase

The cellular phase of acute inflammation is a tightly orchestrated sequence of events that recruits leukocytes, primarily neutrophils, to sites of tissue injury or infection. Following the initial vascular changes, this phase ensures effective immune cell migration, activation, and function at the affected site to eliminate pathogens and initiate tissue repair.Leukocyte Recruitment CascadeLeukocyte recruitment happens in four steps: margination, adhesion, transmigration, and chemotaxis. Reduced...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

FACS-based detection of extracellular ASC specks from NLRP3 inflammasomes in inflammatory diseases.

Clinical and experimental immunology·2024

Same author

Characterization of Genetic Landscape and Novel Inflammatory Biomarkers in Patients With Adult-Onset Still's Disease.

Arthritis & rheumatology (Hoboken, N.J.)·2024

Same author

Anti-inflammatory effects of elexacaftor/tezacaftor/ivacaftor in adults with cystic fibrosis heterozygous for F508del.

PloS one·2024

Same author

Inflammatory profile of lower risk myelodysplastic syndromes.

British journal of haematology·2024

Same author

A nosology of immune diseases from deep immunophenotyping.

Nature reviews. Rheumatology·2024

Same author

Novel Targeted Therapies for Rheumatoid Arthritis Based on Intracellular Signalling and Immunometabolic Changes: A Narrative Review.

Frontiers in bioscience (Landmark edition)·2024

Search research articles

Related Experiment Video

Updated: Jun 27, 2026

Teasing Out the Interplay Between Natural Killer Cells and Nociceptor Neurons

Teasing Out the Interplay Between Natural Killer Cells and Nociceptor Neurons

Published on: June 30, 2022

NOD-like receptors and inflammation.

Rebeccah J Mathews¹, Michael B Sprakes, Michael F McDermott

¹Section of Musculoskeletal Disease, Leeds Institute of Molecular Medicine, St James's University Hospital, Leeds, UK.

Arthritis Research & Therapy

|December 19, 2008

Summary

Nucleotide-binding and oligomerization domain, leucine-rich repeat (NLR) proteins are key in innate immunity and disease. Targeting NLR pathways shows promise for treating inflammatory disorders.

Area of Science:

Immunology
Genetics
Pharmacology

Background:

Nucleotide-binding and oligomerization domain, leucine-rich repeat (NLR) proteins are intracellular sensors.
NLRs recognize pathogen components and cellular stress signals.
Aberrant NLR function contributes to monogenic and polygenic diseases.

Purpose of the Study:

To review the role of NLRs in inflammatory diseases.
To discuss therapeutic strategies targeting NLR pathways.

Main Methods:

Literature review of NLR function in disease.
Analysis of current therapeutic approaches targeting NLRs.

Main Results:

NLRs activate innate immunity and pro-inflammatory pathways (e.g., IL-1beta, NF-kappaB).

More Related Videos

Increased Recovery Time and Decreased LPS Administration to Study the Vagus Nerve Stimulation Mechanisms in Limited Inflammatory Responses

Increased Recovery Time and Decreased LPS Administration to Study the Vagus Nerve Stimulation Mechanisms in Limited Inflammatory Responses

Published on: March 29, 2017

Related Experiment Videos

Last Updated: Jun 27, 2026

Teasing Out the Interplay Between Natural Killer Cells and Nociceptor Neurons

Teasing Out the Interplay Between Natural Killer Cells and Nociceptor Neurons

Published on: June 30, 2022

Increased Recovery Time and Decreased LPS Administration to Study the Vagus Nerve Stimulation Mechanisms in Limited Inflammatory Responses

Increased Recovery Time and Decreased LPS Administration to Study the Vagus Nerve Stimulation Mechanisms in Limited Inflammatory Responses

Published on: March 29, 2017

Targeting NLRs has shown success in treating specific inflammatory disorders.

Conclusions:

NLRs are critical mediators of inflammation and disease.
Therapeutic targeting of NLRs represents a promising strategy for inflammatory conditions.