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Incidence, organ dysfunction and mortality in severe sepsis: a Spanish multicentre study
Jesús Blanco1, Arturo Muriel-Bombín, Víctor Sagredo
1Critical Care Department, Nuevo Hospital Universitario Río Hortega, Calle Dulzaina s/n, 47012 Valladolid, Spain. jblanco@hurh.sacyl.es
Critical Care (London, England)
|December 19, 2008
Summary
Severe sepsis is common in intensive care units (ICUs), with high mortality rates. Delays in diagnosis and treatment likely contribute to poor outcomes, especially in the early stages of sepsis.
Area of Science:
- Critical Care Medicine
- Infectious Diseases
- Epidemiology
Background:
- Sepsis is a major cause for ICU admission and a leading cause of death in ICUs.
- Presents the first extensive epidemiological data on severe sepsis in Spanish ICUs.
Purpose of the Study:
- Determine the incidence of severe sepsis in Spanish ICUs.
- Analyze early (48-hour) and hospital mortality rates.
- Identify risk factors associated with sepsis-related death.
Main Methods:
- Prospective, observational, multicenter cohort study.
- Conducted over two 3-month periods in 2002 in Spain.
- Included adult patients admitted to ICUs.
Main Results:
- Severe sepsis incidence was 25 cases per 100,000 inhabitants/year.
- Hospital mortality was 54.3%, with 48.2% in the ICU.
- Early death (48h) was 14.8%; associated with hematological/liver failure, prior infection, and LODS score.
- Hospital death associated with age, alcohol abuse, McCabe score, LODS, DeltaSOFA, and SOFA AUC.
Conclusions:
- High incidence and mortality rates for severe sepsis in ICUs were observed.
- High prevalence of organ failure and early mortality suggest diagnostic and treatment delays.
- Urgent diagnosis, resuscitation, and antibiotic initiation are critical for improving sepsis outcomes.
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