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Related Concept Videos

Ischemic Stroke l: Introduction01:15

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
Aneurysm II: Clinical Manifestations and Diagnostic Studies01:21

Aneurysm II: Clinical Manifestations and Diagnostic Studies

Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
Stroke: Introduction and Types01:29

Stroke: Introduction and Types

A stroke is an acute neurological event caused by the sudden disruption of cerebral blood flow, leading to rapid loss of neuronal function. Neurons depend on continuous oxygen and glucose supply, so even brief interruptions can cause irreversible injury within minutes. Strokes are classified into ischemic and hemorrhagic types.Ischemic StrokeIschemic strokes are most common and occur due to arterial occlusion, depriving brain tissue of oxygen and nutrients. This leads to energy failure, ionic...
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Atherosclerosis IV: Nursing Management

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Related Experiment Video

Updated: Jun 27, 2026

Quantification of Atherosclerosis in Mice
06:59

Quantification of Atherosclerosis in Mice

Published on: June 12, 2019

Aortic arch plaque in stroke.

Souvik Sen1

  • 1UNC Stroke Center, Department of Neurology, University of North Carolina, 7001 NC Neuroscience Hospital, CB# 7025, Chapel Hill, NC 27599-7025, USA. SenS@neurology.unc.edu

Current Cardiology Reports
|December 19, 2008
PubMed
Summary
This summary is machine-generated.

Severe aortic arch plaque significantly increases stroke risk. Current evidence suggests oral anticoagulation and statins may help prevent stroke, but further research is needed.

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Last Updated: Jun 27, 2026

Quantification of Atherosclerosis in Mice
06:59

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Published on: June 12, 2019

Isolation and Analysis of Aortic Arch and Root Lesions in an Atherosclerotic Mouse Model
07:49

Isolation and Analysis of Aortic Arch and Root Lesions in an Atherosclerotic Mouse Model

Published on: February 14, 2025

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07:51

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Published on: January 13, 2012

Area of Science:

  • Cardiovascular Medicine
  • Neurology
  • Vascular Surgery

Background:

  • Severe aortic arch plaque is a significant risk factor for stroke.
  • The relationship between aortic plaque and stroke presents diagnostic and therapeutic challenges.

Purpose of the Study:

  • To review the association between aortic arch plaque and stroke.
  • To discuss diagnostic imaging modalities and therapeutic strategies for preventing stroke from aortic plaque.

Main Methods:

  • Review of current imaging modalities for aortic plaque evaluation.
  • Analysis of retrospective data on stroke prevention in patients with severe aortic plaque.
  • Discussion of risks associated with invasive vascular procedures and cardiovascular surgery.

Main Results:

  • Retrospective data suggest oral anticoagulation and statins may reduce stroke risk in patients with severe aortic plaque.
  • Iatrogenic embolization is a risk during invasive procedures.
  • Therapy to prevent emboli from aortic plaque is not yet established.

Conclusions:

  • Assessing aortic arch plaque is crucial for stroke risk stratification.
  • Specific prevention strategies, potentially including anticoagulation and statins, may mitigate stroke risk.
  • Careful consideration of risks versus benefits is needed for invasive procedures in these patients.