Related Experiment Video
Updated: Jun 27, 2026
04:45
Intraoperative Assessment of Resection Margins in Oral Cavity Cancer: This is the Way
Published on: May 10, 2021
[Margin status in invasive breast cancer].
G Houvenaeghel1, E Lambaudie, M Buttarelli
1Institut Paoli-Calmettes, Marseille, France.
Bulletin Du Cancer
|December 19, 2008
Summary
Optimizing surgical margins in breast-conserving surgery can reduce local recurrence rates. Achieving negative margins, ideally 2mm, is crucial for better outcomes in breast cancer treatment.
Area of Science:
- Oncology
- Surgical Pathology
- Breast Cancer Research
Context:
- Breast-conserving surgery and mastectomy offer equivalent overall survival rates.
- Breast-conserving surgery has a higher rate of local recurrence compared to mastectomy.
- Identified predictive factors for local recurrence include margins of resection, radiation therapy, chemotherapy, and hormonotherapy, with potential for modification.
Purpose:
- To review existing literature and define optimal margins of resection for breast-conserving surgery.
- To emphasize the importance of specimen orientation and lateral margin inking for accurate histopathological analysis.
- To investigate the correlation between positive margins and local recurrence rates, as well as the impact of re-excision.
Summary:
- Lateral margins are critical due to proximity to the pectoral muscle, and positive margins are linked to higher local recurrence.
- While no universal consensus exists, a 2mm margin appears to reduce local recurrence.
- The study also considers the influence of extensive intraductal components on local recurrence risk.
Impact:
- Establishing optimal margin guidelines can improve surgical outcomes and reduce the need for re-excision.
- This research can inform surgical decision-making and enhance the effectiveness of breast-conserving procedures.
- Further investigation into independent predictive factors for local recurrence is warranted to refine treatment strategies.