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Whole-brain perfusion CT performed with a prototype 256-detector row CT system: initial experience.
Kazuhiro Murayama1, Kazuhiro Katada, Masato Nakane
1Department of Radiology, Faculty of Radiological Technology, School of Health Sciences, Fujita Health University, Toyoake, Aichi 470-1192, Japan. kmura@fujita-hu.ac.jp
Radiology
|December 19, 2008
Summary
Whole-brain perfusion CT using a 256-detector row system effectively assesses ischemic cerebrovascular disease. This advanced imaging technique offers improved diagnostic utility by identifying ischemic regions in a single examination.
Area of Science:
- Neurology
- Radiology
- Medical Imaging
Background:
- Ischemic cerebrovascular disease diagnosis relies on accurate imaging of cerebral blood flow.
- Current perfusion imaging techniques may have limitations in covering the entire brain.
- Advanced computed tomography (CT) systems offer potential for improved diagnostic capabilities.
Purpose of the Study:
- To evaluate the feasibility of whole-brain perfusion CT with a prototype 256-detector row CT system.
- To assess the diagnostic utility of this extended-range whole-brain perfusion CT for ischemic cerebrovascular disease.
- To compare whole-brain perfusion CT with conventional imaging methods.
Main Methods:
- Retrospective evaluation of 11 cases (10 subjects) with intra- or extracranial stenosis using whole-brain perfusion CT.
- Independent assessment of perfusion CT data by three readers using a three-point scale.
- Comparison of whole-brain perfusion CT with four-section imaging and single photon emission computed tomography (SPECT) in a subset of subjects.
Main Results:
- Whole-brain perfusion CT images demonstrated the extent of ischemia effectively.
- Mean visual evaluation scores were significantly higher for whole-brain images compared to four-section images.
- A significant positive correlation was found between cerebral blood flow ratios from perfusion CT and SPECT (R(2) = 0.76).
Conclusions:
- Perfusion CT with a 256-detector row system enables whole-brain assessment after a single contrast medium bolus.
- This technique can identify ischemic regions in one examination, potentially enhancing diagnostic utility.
- The findings support the feasibility and diagnostic value of extended-range whole-brain perfusion CT.
