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Related Concept Videos

Bone Remodeling

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.

Bone Remodeling and Repair

Bone Remodeling and Repair

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...

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Can experimental data in humans verify the finite element-based bone remodeling algorithm?

Christian Wong¹, P Martin Gehrchen, Thomas Kiaer

¹Department of Orthopaedic Surgery, National University Hospital of Copenhagen, Copenhagen, Denmark. chwo123@gmail.com

|December 19, 2008

Summary

This summary is machine-generated.

This study compared bone remodeling algorithms to patient data after lumbar spine surgery with pedicle screws. The algorithms did not accurately predict bone loss or gain, failing to validate their use in clinical settings.

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Area of Science:

Biomechanical engineering
Spinal surgery
Bone physiology

Background:

Bone remodeling algorithms require experimental validation in human spines.
Previous studies lacked experimental comparison for spinal bone remodeling algorithms.

Purpose of the Study:

Evaluate the validity of two bone remodeling algorithms against prospective bone mineral content data.
Examine the stress shielding effect using these algorithms and experimental data.

Main Methods:

Applied site-specific and nonsite-specific iterative bone remodeling algorithms to a finite element model of the lumbar spine (L4-L5) with pedicle screws.
Compared algorithm results with bone mineral content measurements from four patients at 3, 6, and 12 months post-surgery.
Assessed the stress shielding effect.

Main Results:

Experimental data showed an average bone loss of 9.78% below pedicle screws after one year.
The bone remodeling algorithms predicted average bone gains of 8.41% and 1.61%.
No correlation was found between the predicted bone remodeling and the experimental measurements.

Conclusions:

The evaluated bone remodeling algorithms did not demonstrate validity when compared to prospective bone mineral content measurements.
The study could not confirm the predictive accuracy of the bone remodeling algorithms for human lumbar spine surgery outcomes.