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Switch from conventional to every other day hemodialysis: a comparison pilot study
Konstantinos P Katopodis1, Evangelia Dounousi, Anna Challa
1Department of Nephrology, University Hospital of Ioannina, and Child Health Institute, University of Ioannina, Greece.
ASAIO Journal (American Society for Artificial Internal Organs : 1992)
|December 19, 2008
Summary
Every other day hemodialysis (eodHD) offers significant benefits over conventional hemodialysis (cHD), improving blood pressure, cardiac function, and reducing symptoms. This alternative dialysis schedule may enhance patient outcomes.
Area of Science:
- Nephrology
- Cardiology
- Internal Medicine
Background:
- Conventional hemodialysis (cHD) is associated with weekly fluid and solute fluctuations, negatively impacting patient outcomes.
- Managing these fluctuations is crucial for improving the quality of life and clinical status of patients with kidney disease.
Purpose of the Study:
- To evaluate the clinical and laboratory effects of every other day hemodialysis (eodHD) compared to cHD.
- To assess the potential advantages of eodHD in improving patient outcomes.
Main Methods:
- Eighteen patients on cHD were studied over 12 months.
- Nine patients were randomly switched to eodHD (group I), while nine continued with cHD (group II).
- Clinical parameters (body weight, blood pressure, antihypertensive use, cardiac function) and laboratory markers (hemoglobin, erythropoietin dose, delivered dialysis dose - dpKt/V) were monitored.
Main Results:
- Group I (eodHD) showed reduced body weight, mean blood pressure, and antihypertensive use (p<0.05).
- Significant improvements in left ventricular mass and ejection fraction were observed in group I.
- Erythropoietin dose decreased, delivered dialysis dose (dpKt/V) increased, and urea rebound lessened in group I.
- Uremia-related and postdialysis symptoms improved in the eodHD group.
Conclusions:
- Every other day hemodialysis (eodHD) demonstrates significant clinical and biochemical improvements compared to conventional hemodialysis (cHD).
- eodHD may offer advantages in patient outcomes, including better blood pressure control, cardiac function, and symptom management.
- This dialysis schedule warrants consideration for improving the overall well-being of hemodialysis patients.
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