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Updated: Jun 27, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

[Bufexamac-induced pigmented purpuric eruption].

K Waltermann¹, W Ch Marsch, B Kreft

¹Klinik für Dermatologie, Venerologie und Allergie, Universitätsklinikum Essen, Hufelandstrasse 55, 45122, Essen, Deutschland. katharina.waltermann@uk-essen.de

Der Hautarzt; Zeitschrift Fur Dermatologie, Venerologie, Und Verwandte Gebiete

|December 19, 2008

Summary

This summary is machine-generated.

Bufexamac caused allergic contact dermatitis that spread through the bloodstream, presenting as a pigmented purpuric eruption. This is the first documented case of bufexamac-induced pigmented purpuric dermatosis.

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Last Updated: Jun 27, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

Area of Science:

Dermatology
Toxicology

Background:

Bufexamac is a topical anti-inflammatory agent.
Cutaneous adverse drug reactions are a known concern with topical medications.

Observation:

A patient developed allergic contact dermatitis after bufexamac application.
The dermatitis exhibited hematogenous dissemination.
The presentation mimicked a pigmented purpuric eruption clinically and histologically.

Findings:

This case represents the first report of bufexamac-induced pigmented purpuric dermatosis.
Bufexamac can cause a diverse range of cutaneous side-effects.

Implications:

Highlights the potential for bufexamac to cause systemic allergic reactions.
Emphasizes the importance of considering drug-induced dermatoses in differential diagnosis.
Underscores the need for vigilance regarding bufexamac's side effect profile.