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Practical methods for chemical inactivation of Creutzfeldt-Jakob disease pathogen
J Tateishi1, T Tashima, T Kitamoto
1Department of Neuropathology, Faculty of Medicine, Kyushu University, Fukuoka.
Microbiology and Immunology
|January 1, 1991
Abstract:
Chemical inactivation of pathogen of Creutzfeldt-Jakob disease (CJD) was examined using the mouse-adapted CJD strain. A high concentration of formic acid, guanidine compounds, trichloroacetate and phenol prevented CJD transmission. NaOH between 0.25 and 2 N lengthened the incubation periods. Sodium dodecyl sulfate (SDS) in a concentration between 1 and 3% did not alter incubation at room temperature but did completely block the transmission after boiling for 3 min in 3% SDS. This method is recommended for practical disinfection.