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Mouse Heterotopic Cervical Cardiac Transplantation Utilizing Vascular Cuffs
Published on: June 23, 2022
[Mechanical circulation support as emergency bridging for heart transplantation]
Xin-jin Luo1, Sheng-shou Hu, Han-song Sun
1Department of Cardiovascular Surgery, Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. luoxinjin@yahoo.com
Zhonghua Wai Ke Za Zhi [Chinese Journal of Surgery]
|December 20, 2008
Summary
Mechanical circulatory support (MCS) devices can be beneficial for patients with acute cardiogenic shock awaiting heart transplantation. Early MCS intervention improves outcomes and identifies suitable candidates before organ failure.
Area of Science:
- Cardiology
- Transplantation Medicine
- Mechanical Circulatory Support
Context:
- Acute cardiogenic shock presents a critical challenge in heart failure management.
- Mechanical circulatory support (MCS) devices are increasingly utilized for patients awaiting heart transplantation.
- Pretransplant evaluation timelines are often abbreviated in emergent situations.
Purpose:
- To investigate the outcomes of patients with acute cardiogenic shock requiring MCS prior to standard heart transplant evaluations.
- To assess the efficacy and safety of early MCS initiation in critically ill cardiac patients.
Summary:
- Ten patients with acute cardiogenic shock received emergency MCS (ECMO, BVS5000, MEDOS) bridging to transplantation.
- Patients experienced varied outcomes, including successful transplantation (4), recovery (2), and mortality (2) due to embolism or organ failure.
- Two patients' MCS was terminated due to infection, leading to unfavorable outcomes.
Impact:
- Early MCS support in acute cardiogenic shock appears warranted, improving outcomes.
- Timely MCS initiation can prevent multiple organ system failure and identify transplant candidates.
- This approach highlights the importance of MCS in managing catastrophic cardiac events.
