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Related Concept Videos

Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Cellular Adaptation IV: Dysplasia and Metaplasia01:24

Cellular Adaptation IV: Dysplasia and Metaplasia

DysplasiaDysplasia refers to abnormal changes in the size, shape, and organization of mature cells, characterized by pleomorphism, nuclear abnormalities, and increased mitotic activity. It commonly affects epithelial tissues, including the cervix, gastrointestinal tract, respiratory mucosa, and endometrium. Although it may occur alongside hyperplasia, dysplasia is not a true adaptive response but a preneoplastic change with potential to progress to cancer.When confined above the basement...
Papillary Dermis01:11

Papillary Dermis

Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen and...
Pigmentation01:19

Pigmentation

The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Desmosomes01:05

Desmosomes

The term desmosome derives from the Greek words "desmo" and "soma" meaning "adhesion bodies." This structure was first observed during the late 1800s and described as small, dense nodules in the epidermis. Desmosomes are button-like structures that help form an interlinked network of intermediate filaments across the cells. These junctions are  essential to hold cells together under mechanical stress and to maintain tissue integrity. Desmosomes are multi-protein complexes comprising desmosomal...

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Related Experiment Video

Updated: Jun 27, 2026

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia
06:15

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

The "dysplastic" nevus.

Robert J Friedman1, Michele J Farber, Melanie A Warycha

  • 1Department of Dermatology, New York University School of Medicine, New York, NY 10016, USA. rfriedmanmdceo@hotmail.com

Clinics in Dermatology
|December 20, 2008
PubMed
Summary
This summary is machine-generated.

Dysplastic nevi are linked to increased melanoma risk, though their significance and management remain debated. Research covers their history, genetics, and clinical features, guiding current surveillance and biopsy recommendations.

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Area of Science:

  • Dermatology
  • Oncology
  • Pathology

Background:

  • Dysplastic nevi are increasingly recognized clinically.
  • Evidence suggests a correlation between dysplastic nevi and a higher risk of melanoma development.
  • Contention exists regarding the clinical significance and precise definition of dysplastic nevi.

Purpose of the Study:

  • To provide a comprehensive overview of dysplastic nevi.
  • To examine the history, epidemiology, genetics, and clinical/histologic features of dysplastic nevi.
  • To discuss current clinical management procedures and future technological impacts.

Main Methods:

  • Literature review and synthesis of existing research on dysplastic nevi.
  • Analysis of historical data, epidemiological studies, and genetic research.
  • Examination of clinical and histological diagnostic criteria and management guidelines.

Main Results:

  • Dysplastic nevi were first described in 1978.
  • Significant research exists on the epidemiology and genetics of dysplastic nevi.
  • Disagreement persists on the clinical management and histological definition of dysplastic nevi.

Conclusions:

  • Current management involves preventative measures like sun protection and surveillance.
  • Biopsies are recommended for suspicious lesions.
  • Emerging technologies, such as computer-vision systems, may influence future treatment paradigms for dysplastic nevi.