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Updated: Jun 27, 2026
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Cercosporin-Photocatalyzed [4+1]- and [4+2]-Annulations of Azoalkenes Under Mild Conditions
Published on: July 17, 2020
Organocatalyzed highly atom economic one pot synthesis of tetrahydropyridines as antimalarials
Mridul Misra1, Swaroop Kumar Pandey, Vivek Parashar Pandey
1Medicinal and Process Chemistry, Central Drug Research Institute, Lucknow, UP 226001, India.
Abstract:
A highly atom economic one pot synthesis of tetrahydropyridines was achieved by L-proline/TFA catalysed multicomponent reaction of beta-keto-esters, aromatic aldehydes and anilines. The synthesized compounds were screened against Plasmodium falciparum in vitro and one of them showed antimalarial activity with MIC as low as 0.09 microg/mL.
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