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Neuronal Interfaces in Bioelectronic Medicines for Unlocking Therapeutic Potential for ANS Issues
Gunjan1, Shaweta Sharma1, Jyoti Pandey1
1Department of Pharmacy, School of Medical and Allied Sciences, Galgotias University, Greater Noida, U.P., India.
Current Drug Research Reviews
|July 6, 2026
Summary
Bioelectronic devices precisely modulate the autonomic nervous system (ANS) for targeted disease treatment. Advancements in neurotechnology offer new therapeutic options for various conditions, though challenges remain in standardization and patient-specific applications.
Area of Science:
- Bioelectronic Medicine
- Neurotechnology
- Biocompatible Materials
Background:
- Developments in neurotechnology, micro/nano-engineering, and biocompatible materials enable bioelectronic devices to modulate autonomic nervous system (ANS) activity.
- These devices offer potential treatments for a variety of disorders by altering ANS function.
Purpose of the Study:
- To explore how bioelectronic devices can modify ANS activity for treating various illnesses.
- To discuss preclinical and clinical applications, electrode technology advancements, and challenges in neuromodulation.
Main Methods:
- Review of preclinical and clinical studies on bioelectronic devices for ANS modulation.
- Emphasis on electrode technology developments and their efficacy in treating metabolic, inflammatory, cardiovascular, and pelvic conditions.
Main Results:
- Neuronal interfaces allow precise ANS neuromodulation for targeted therapies.
- Clinical successes include vagus nerve stimulation (VNS) for rheumatoid arthritis and diabetes.
- Challenges include foreign body response, glial scarring, and limited large-scale ANS-specific trials.
Conclusions:
- Bioelectronic medicine offers targeted ANS therapies for conditions like inflammation, hypertension, and GI dysmotility.
- Future research should focus on integrative approaches and technological advancements to overcome current limitations.
- Case studies highlight the use of bioelectronic medicines in autonomic disorders.
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