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Updated: Jul 4, 2026
09:03
Manufacture and Drug Delivery Applications of Silk Nanoparticles
Published on: October 8, 2016
Polymeric Nanocarriers in Drug Delivery.
Harshit Kumar Maurya1, Shaweta Sharma1
1Department of Pharmacy, School of Medical and Allied Sciences, Galgotias University, Greater Noida, U.P., India.
Pharmaceutical Nanotechnology
|July 3, 2026
Summary
Polymeric nanocarriers offer advanced solutions for drug delivery challenges like poor solubility and toxicity. This review details their development, applications, and future potential in personalized nanomedicine.
Area of Science:
- Biomedical Engineering
- Materials Science
- Pharmacology
Background:
- Pharmacotherapy is evolving towards precision nanomedicine, moving beyond traditional drug delivery systems.
- Polymeric nanocarriers (nanospheres, nanocapsules, micelles, dendrimers, polymersomes, nanogels) address limitations like low solubility, rapid clearance, and toxicity.
Purpose of the Study:
- To critically review recent advancements in polymeric nanocarrier systems.
- To focus on structural differentiation, physicochemical properties, and biological activity.
- To analyze fabrication methods, drug delivery strategies, and emerging trends.
Main Methods:
- Review of natural and synthetic polymers for biodegradability, biocompatibility, and functionality.
- Critical analysis of fabrication methods (e.g., nanoprecipitation, dendrimer synthesis) concerning industrial scale-up.
- Systematic analysis of drug delivery approaches: passive (EPR effect), active (ligand-mediated), and stimuli-responsive release.
Main Results:
- Exploration of polymeric nanocarriers' structural diversity, properties, and biological impact.
- Evaluation of fabrication techniques and their industrial translation challenges.
- Detailed examination of various drug delivery mechanisms and emerging trends like hybrid nanostructures and green synthesis.
Conclusions:
- Polymeric nanocarriers are versatile platforms with significant potential for next-generation drug delivery.
- Emerging trends include AI integration for formulation design and a shift towards personalized nanomedicine.
- Clinical advancements and FDA-approved formulations highlight the growing importance and viability of these systems.
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