Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Therapeutic Drug Monitoring: Drug Analysis Methods

Therapeutic Drug Monitoring: Drug Analysis Methods

Therapeutic Drug Monitoring (TDM) is a clinical practice that measures specific drug levels in a patient's blood or body tissues to tailor drug therapy effectively. This monitoring is critical for managing drugs with narrow therapeutic indices like digoxin and phenytoin, ensuring they are both safe and effective. For instance, monitoring theophylline levels in asthma patients involves precision and sensitivity to adjust doses according to individual responses to therapy, ensuring efficacy and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Precision oncology's translation gap-Can molecular tumor boards bridge it?

PLoS medicine·2026

Same author

A case report of acute carcinoid heart failure during lutetium-177 dotatate-triapine treatment for well-differentiated neuroendocrine tumors.

Frontiers in oncology·2026

Same author

A Phase 1 Dose Escalation of Lapatinib and Paclitaxel in Recurrent Ovarian Cancer.

Cancers·2026

Same author

Inhibition of fatty acid synthase enhances therapeutic efficacy and delays acquired resistance to BRAF-targeted therapy in colorectal cancer.

Neoplasia (New York, N.Y.)·2026

Same author

Assessing the Value of Sequential Next-Generation Sequencing and Multiple Molecular Tumor Board Reviews for Patients With Solid-Tumor Malignancies.

JCO precision oncology·2026

Same author

M1 Macrophage-Engineered Vesicles Have Anti-Cancer Activity in Ovarian Cancer.

Cancer nanotechnology·2026

Same journal

Thanks to CMS Rule Change, MA Takes SDOH to a Whole New Level.

Managed care (Langhorne, Pa.)·2019

Same journal

Hail, Not Frail! MA's Wellness Reach Expands.

Managed care (Langhorne, Pa.)·2019

Same journal

To Be Continued:The Search for a Cure for HIV.

Managed care (Langhorne, Pa.)·2019

Same journal

Once-a-day HIV Treatment: Pricey But Perhaps Worth It.

Managed care (Langhorne, Pa.)·2019

Same journal

In Trump, HIV/AIDS Groups Find an Ally Who's Tough To Love.

Managed care (Langhorne, Pa.)·2019

Same journal

Air Ambulance Turbulence: Consolidation, Cost Shifting, and Surprise Billing.

Managed care (Langhorne, Pa.)·2019

See all related articles

Search research articles

Related Experiment Video

Updated: Jun 27, 2026

Developing Custom Chinese Hamster Ovary-host Cell Protein Assays using Acoustic Membrane Microparticle Technology

Developing Custom Chinese Hamster Ovary-host Cell Protein Assays using Acoustic Membrane Microparticle Technology

Published on: February 3, 2011

Assessing therapeutically developed assays.

Jill M Kolesar¹

¹Analytical Instrumentation Laboratory for Pharmacokinetics, Pharmacodynamics, and Pharmacogenetics, University of Wisconsin, Paul P. Carbone Comprehensive Cancer Center, Madison, USA.

Managed Care (Langhorne, Pa.)

|December 20, 2008

Summary

This summary is machine-generated.

Gene expression profiling helps classify early-stage breast cancer, leading to significant drug cost savings. Using validated molecular diagnostics can improve patient quality of life and reduce healthcare expenses.

More Related Videos

Detection of Antibodies That Neutralize the Cellular Uptake of Enzyme Replacement Therapies with a Cell-based Assay

Detection of Antibodies That Neutralize the Cellular Uptake of Enzyme Replacement Therapies with a Cell-based Assay

Published on: September 10, 2018

Drug-induced Sensitization of Adenylyl Cyclase: Assay Streamlining and Miniaturization for Small Molecule and siRNA Screening Applications

Drug-induced Sensitization of Adenylyl Cyclase: Assay Streamlining and Miniaturization for Small Molecule and siRNA Screening Applications

Published on: January 27, 2014

Related Experiment Videos

Last Updated: Jun 27, 2026

Developing Custom Chinese Hamster Ovary-host Cell Protein Assays using Acoustic Membrane Microparticle Technology

Developing Custom Chinese Hamster Ovary-host Cell Protein Assays using Acoustic Membrane Microparticle Technology

Published on: February 3, 2011

Detection of Antibodies That Neutralize the Cellular Uptake of Enzyme Replacement Therapies with a Cell-based Assay

Detection of Antibodies That Neutralize the Cellular Uptake of Enzyme Replacement Therapies with a Cell-based Assay

Published on: September 10, 2018

Drug-induced Sensitization of Adenylyl Cyclase: Assay Streamlining and Miniaturization for Small Molecule and siRNA Screening Applications

Drug-induced Sensitization of Adenylyl Cyclase: Assay Streamlining and Miniaturization for Small Molecule and siRNA Screening Applications

Published on: January 27, 2014

Area of Science:

Oncology
Molecular Diagnostics
Health Economics

Background:

Early-stage breast cancer treatment decisions benefit from accurate risk stratification.
Gene expression profiling offers a method for molecular subtyping of tumors.

Purpose of the Study:

To evaluate the economic impact of using gene expression profiling for risk classification in early-stage breast cancer.
To assess the potential for cost savings and improved patient outcomes through molecular diagnostics.

Main Methods:

Economic analysis of treatment strategies based on gene expression profiling.
Review of clinical validation data for molecular diagnostic tools in breast cancer.

Main Results:

Risk classification via gene expression profiling can lead to substantial reductions in drug expenditures.
Molecular diagnostics demonstrate potential for significant cost savings in breast cancer management.

Conclusions:

Clinically validated molecular diagnostics are crucial for cost-effective breast cancer care.
The appropriate use of gene expression profiling can optimize treatment selection and enhance patient quality of life while reducing healthcare costs.