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Related Concept Videos

Curing of Concrete01:20

Curing of Concrete

359
The hydration of cement takes place within the water-filled capillary pores. However, environmental elements can disrupt this process by evaporating water from the concrete surfaces. Sealed concrete with a water-cement ratio below 0.5 experiences self-desiccation, leading to water loss. The water loss in concrete is mitigated by curing. This technique involves keeping the concrete saturated to maintain the necessary temperature and moisture conditions, to optimally fill the spaces in the cement...
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Curing Methods01:26

Curing Methods

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Concrete members with a small surface-to-volume ratio are cured by oiling and moistening the forms before casting the concrete member. These forms can be left in place for a prolonged period to prevent moisture loss, and can be wetted if made of a material suitable for wetting. If the forms are removed early, the concrete member is moistened and covered with polythene sheets to maintain moisture. For large horizontal concrete surfaces exposed to dry weather, a temporary covering is suspended...
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Accelerated Curing of Concrete01:25

Accelerated Curing of Concrete

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Accelerating concrete curing is achieved by applying heat and additional moisture. This process accelerates the hydration of the cement, resulting in an earlier strength gain in the concrete. Steam curing is a method wherein the concrete products are either transported through a chamber on a conveyor belt or encased in plastic, allowing steam at atmospheric pressure to circulate freely around them. This process begins with a phase of moist curing that typically lasts between 3 to 5 hours, after...
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Viral Mutations00:36

Viral Mutations

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A mutation is a change in the sequence of bases of DNA or RNA in a genome. Some mutations occur during replication of the genome due to errors made by the polymerase enzymes that replicate DNA or RNA. Unlike DNA polymerase, RNA polymerase is prone to errors because it is not capable of “proofreading” its work. Viruses with RNA-based genomes, like HIV, therefore accrue mutations faster than viruses with DNA-based genomes. Because mutation and recombination provide the raw material...
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Confirmation Biases01:31

Confirmation Biases

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The confirmation bias is the tendency to focus on information that confirms our existing beliefs and ignore information that is inconsistent with our expectations. For example, if you think that your professor is not very nice, you notice all of the instances of rude behavior exhibited by the professor while ignoring the countless pleasant interactions he is involved in on a daily basis. Have you ever fallen prey to the confirmation bias, either as the source or target of such bias?
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Updated: Jan 23, 2026

Rapid Screening of HIV Reverse Transcriptase and Integrase Inhibitors
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To Be Continued:The Search for a Cure for HIV.

Thomas Reinke

    Managed Care (Langhorne, Pa.)
    |June 13, 2019
    PubMed
    Summary

    Researchers are exploring two new HIV cure strategies: a sterilizing cure to eliminate the virus and a functional cure to control viral load and prevent AIDS progression.

    Area of Science:

    • Immunology
    • Virology
    • Infectious Diseases

    Background:

    • Antiretroviral therapy has significantly reduced HIV/AIDS mortality and transmission.
    • Complete eradication of HIV remains a major challenge in clinical management.
    • Persistent viral reservoirs complicate efforts to achieve a definitive cure.

    Purpose of the Study:

    • To investigate novel therapeutic approaches for HIV/AIDS.
    • To evaluate the potential of sterilizing and functional cures for HIV.
    • To assess strategies for viral load reduction and elimination.

    Main Methods:

    • Clinical trials evaluating novel "sterilizing cure" strategies.
    • Studies assessing "functional cure" interventions to control viral load.
    • Research into methods for eradicating latent HIV reservoirs.
    Keywords:
    Acquired Immunodeficiency SyndromeHIV Infections

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    Main Results:

    • Sterilizing cure approaches aim for complete HIV eradication from the body.
    • Functional cure strategies focus on long-term viral load suppression below detectable levels.
    • Both approaches seek to prevent disease progression and transmission.

    Conclusions:

    • Sterilizing and functional cures represent distinct but promising avenues for HIV/AIDS treatment.
    • Advancements in HIV cure research offer hope for improved patient outcomes.
    • Further clinical evaluation is necessary to determine the efficacy and safety of these innovative strategies.