[Ultrastructural changes in the liver in experimental hypothyroidism]

Electron microscopic studies of the liver of thyroidectomized rabbits were carried out. Ultrastructural changes in hepatocytes at various periods after the operation were established. Morphological changes in hepatic cells occurred already at early stages of hypothyrosis (1 month) and led to considerable dystrophyc processes at later stages of the experiment. In the hepatic tissue there was noted a marked myxedema, as well as a considerable intracellular edema which led to destruction of hepatocytes. The studies conducted revealed lesion of the morphological structure of the liver, impairment of general metabolic processes and of the hepatic function.