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Tachycardia-Induced Cardiomyopathy As a Chronic Heart Failure Model in Swine
10:08

Tachycardia-Induced Cardiomyopathy As a Chronic Heart Failure Model in Swine

Published on: February 17, 2018

[64-year old patient with tachycardia and signs of heart failure]

M M Zaruba1, T Waggershauser, S Weckbach

  • 1Medizinische Klinik I, Klinikum Grosshadern, Ludwig-Maximilians-Universität, Marchioninistrasse 15, Munich, Germany. Marc-Michael.Zaruba@med.uni-muenchen.de

Der Internist
|December 23, 2008
PubMed

Insights

Interventional occlusion of liver arterio-venous malformations successfully treated high cardiac output failure in a patient with Morbus Osler. This procedure reduced cardiac output by 25%, improving heart function and clinical stability.

Area of Science:

  • Cardiology
  • Interventional Radiology
  • Hepatology

Background:

  • High cardiac output failure can result from significant arterio-venous malformations (AVMs), posing a therapeutic challenge.
  • Hereditary hemorrhagic telangiectasia (Morbus Osler) is associated with AVMs, including hepatic involvement.

Observation:

  • A 64-year-old patient with Morbus Osler presented with severe right heart insufficiency due to hepatic AVMs.
  • Medical therapy for high cardiac output failure was optimized but insufficient.

Findings:

  • Interventional radiological occlusion of hepatic AVMs was performed in three sessions.
  • The procedure resulted in a 25% reduction in cardiac output (from 20 L/min to 15 L/min).
  • Transient elevation of transaminases was observed and proved reversible.

Implications:

  • Interventional occlusion of hepatic AVMs is an effective treatment for high cardiac output failure in Morbus Osler patients.
  • This approach can lead to reduced diuretic requirements and sustained clinical stabilization.
  • Minimally invasive treatment of visceral AVMs can significantly improve cardiovascular outcomes.

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