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Related Concept Videos

Pleural Disorders: Types and Brief Description01:30

Pleural Disorders: Types and Brief Description

The pleura is a vital part of the respiratory system. It's a double-layered membrane surrounding the lungs and lining the chest cavity. The two layers of the pleura are:
Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...

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Related Experiment Video

Updated: Jun 27, 2026

Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice
07:54

Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice

Published on: December 21, 2019

Malignant mesothelioma.

Alastair J Moore1, Robert J Parker, John Wiggins

  • 1Department of Respiratory Medicine, Wexham Park Hospital, Wexham, Slough, Berkshire, UK. a.moore@ic.ac.uk

Orphanet Journal of Rare Diseases
|December 23, 2008
PubMed
Summary
This summary is machine-generated.

Malignant mesothelioma, a rare asbestos-linked cancer, affects the body's lining cells. Diagnosis requires careful history, imaging, and pathology, with poor prognosis and limited treatment options.

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Orthotopic Implantation and Peripheral Immune Cell Monitoring in the II-45 Syngeneic Rat Mesothelioma Model

Published on: October 2, 2015

Area of Science:

  • Oncology
  • Environmental Medicine
  • Pathology

Background:

  • Malignant mesothelioma is a rare but aggressive cancer linked to asbestos exposure.
  • It affects the mesothelium lining body cavities, with pleural mesothelioma being the most common form.
  • Incidence is rising, with a projected peak in the next 10-20 years.

Purpose of the Study:

  • To summarize the key aspects of malignant mesothelioma, including its causes, diagnosis, and management.
  • To highlight the diagnostic challenges and imaging findings suggestive of malignant pleural disease.
  • To emphasize the importance of a multidisciplinary approach and palliative care.

Main Methods:

  • Review of existing literature on malignant mesothelioma.
  • Analysis of typical and atypical clinical presentations.
  • Identification of key radiological findings on CT scans for diagnosis.
  • Discussion of diagnostic workup involving exposure history, radiology, and pathology.

Main Results:

  • Malignant mesothelioma is strongly associated with occupational asbestos exposure (>90%), but para-occupational, environmental, and idiopathic cases also occur.
  • Common symptoms include chest pain and dyspnea; less common are weight loss and ascites.
  • CT findings like circumferential pleural rind, nodular thickening, and mediastinal involvement suggest malignancy.
  • Distinguishing malignant from benign pleural disease can be difficult.

Conclusions:

  • Accurate diagnosis relies on a combination of exposure history, imaging, and pathology.
  • Multidisciplinary team involvement is crucial for comprehensive management, including radiotherapy, chemotherapy, surgery, and palliative care.
  • Prognosis is poor, with a median survival of approximately one year post-diagnosis.