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Published on: January 28, 2020
Evaluation of apolipoprotein M as a biomarker of coronary artery disease
Weiqiang Su1, Guoqing Jiao, Chengjian Yang
1Department of Cardiovascular Surgery, Affiliated Wuxi 2nd People's Hospital, Nanjing Medical University, Jiangsu, People's Republic of China.
Objective:
To investigate the possible role of apolipoprotein M (ApoM) in the development of coronary artery disease (CAD).
Design And Methods:
Case-controlled study, which consisted of 118 CAD patients and 255 unrelated subjects used as control group. Plasma concentration of ApoM was determined by dot blot, severity of CAD was expressed with Gensini score or the numbers of lesioned coronary arteries, and serum lipid levels were also measured.
Results And Discussion:
Our study shows the mean level of plasma ApoM is 1.3757+/-0.1493 ODu mm(-2) in CAD patients, while it is 1.3502+/-0.1288 ODu mm(-2) in control group, and there are significant differences in plasma level of ApoM between two groups (t=0.032, P<0.05). Concentration of plasma ApoM is positively associated with plasma total cholesterol (r=0.38, P=0.025), high density lipoprotein cholesterol (r=0.29, P=0.03), low density lipoprotein cholesterol (r=0.16, P=0.03) and apolipoproein A-I (r=0.24, P=0.03). Multiple logistic and linear regression analysis showed that plasma concentration of ApoM did not correlate either with the number of lesioned coronaries or the Gensini score after adjusted for conventional cardiovascular risk factors (P>0.05, respectively).
Conclusion:
The findings suggest that ApoM could not be an independent risk factor but a biomarker of CAD.
Insights
Apolipoprotein M (ApoM) levels show a significant difference between coronary artery disease (CAD) patients and controls. However, ApoM is not an independent risk factor for CAD, suggesting it may serve as a biomarker.
Area of Science:
- Cardiovascular Science
- Biochemistry
- Medical Research
Background:
- Coronary artery disease (CAD) is a leading cause of mortality worldwide.
- Apolipoprotein M (ApoM) is a protein found in plasma that has been implicated in lipid metabolism.
- The specific role of ApoM in the pathogenesis of CAD requires further elucidation.
Purpose of the Study:
- To investigate the association between plasma apolipoprotein M (ApoM) levels and the presence and severity of coronary artery disease (CAD).
- To determine if ApoM is an independent risk factor for CAD.
- To explore the relationship between ApoM and established cardiovascular risk factors.
Main Methods:
- A case-controlled study involving 118 CAD patients and 255 controls.
- Plasma ApoM concentration measured using dot blot.
- CAD severity assessed by Gensini score and number of lesioned coronary arteries.
- Serum lipid profiles and apolipoprotein A-I levels were also analyzed.
Main Results:
- Mean plasma ApoM levels were significantly different between CAD patients and controls (P<0.05).
- Plasma ApoM concentration positively correlated with total cholesterol, HDL-C, LDL-C, and apolipoprotein A-I.
- Adjusted regression analyses revealed no significant correlation between plasma ApoM concentration and CAD severity (Gensini score or number of lesioned arteries).
Conclusions:
- Plasma ApoM levels are associated with CAD but do not appear to be an independent risk factor.
- ApoM may serve as a potential biomarker for CAD.
- Further research is warranted to fully understand the clinical utility of ApoM in cardiovascular risk assessment.
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