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CD44 keeps tumor killers polarized
Thorsten R Mempel1, Francesco Marangoni
1Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA. tmempel@mgh.harvard.edu
Immunity
|December 23, 2008
Abstract:
In this issue of Immunity, Mrass et al. (2008) report that CD44 critically contributes to the stabilization of polarity in migrating cytotoxic T lymphocytes by anchoring cytoskeletal proteins to the cell membrane at their uropods.

