Related Experiment Video

Updated: Jun 26, 2026

Echocardiographic Assessment of Cardiac Anatomy and Function in Adult Rats
08:09

Echocardiographic Assessment of Cardiac Anatomy and Function in Adult Rats

Published on: December 13, 2019

Relations between systolic and diastolic function in children with dilated and hypertrophic cardiomyopathy as

Arshiya Mohammed1, Luc Mertens, Mark K Friedberg

  • 1Division of Pediatric Cardiology, The Labatt Family Heart Center, Hospital for Sick Children, Toronto, Ontario, Canada.

Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography
|December 23, 2008
PubMed

Insights

In pediatric dilated cardiomyopathy (DCM) and hypertrophic cardiomyopathy (HCM), systolic and diastolic tissue velocities are linked. This relationship may indicate how systolic function impacts diastolic recoil in children with these heart conditions.

Area of Science:

  • Pediatric Cardiology
  • Cardiovascular Physiology
  • Echocardiography

Background:

  • Dilated cardiomyopathy (DCM) and hypertrophic cardiomyopathy (HCM) are significant pediatric heart conditions.
  • Understanding the interplay between systolic and diastolic function is crucial for managing these diseases.

Purpose of the Study:

  • To investigate the relationship between longitudinal peak systolic tissue velocity (S') and early diastolic tissue velocity (E') in children.
  • To compare these relationships in children with DCM, HCM, and healthy controls.

Main Methods:

  • Tissue Doppler imaging was used to record S' and E' at the lateral mitral annulus and basal interventricular septum.
  • 148 children (0-18 years) were studied: 34 with DCM, 60 with HCM, and 54 controls.
  • Correlations between S', E', and the S'/E' ratio were analyzed, along with other functional indices.

Main Results:

  • A correlation between S' and E' was observed in all groups at both measurement sites.
  • Patients with DCM showed decreased S' and E', while HCM patients had decreased E' with less reduction in S'.
  • The S'/E' ratio correlated with indices of ventricular relaxation and filling.

Conclusions:

  • Longitudinal systolic and diastolic function are interrelated in pediatric DCM and HCM.
  • This relationship may suggest that systolic function influences diastolic recoil in affected children.
  • Findings highlight the complex interplay of cardiac mechanics in pediatric cardiomyopathies.
Abstract

More Related Videos

Echocardiographic Approaches and Protocols for Comprehensive Phenotypic Characterization of Valvular Heart Disease in Mice12:12

Echocardiographic Approaches and Protocols for Comprehensive Phenotypic Characterization of Valvular Heart Disease in Mice

Published on: February 14, 2017

Related Concept Videos

Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
Assessing Blood pressure using a doppler ultrasound01:19

Assessing Blood pressure using a doppler ultrasound

To obtain accurate blood pressure measurements in clinical settings, especially when traditional methods are insufficient, healthcare professionals utilize the Doppler ultrasound technique. This method uses high-frequency sound waves to detect blood flow within the arteries, which is crucial for patients with conditions that complicate circulatory system assessment.
Pre-Procedural Guidelines for Doppler Ultrasound Blood Pressure Assessment:
Preparation of Equipment:
Cardiomyopathy I: Introduction and Classification01:25

Cardiomyopathy I: Introduction and Classification

Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...