Related Experiment Video
Updated: Jun 26, 2026
07:12
Chronic Post-Ischemia Pain Model for Complex Regional Pain Syndrome Type-I in Rats
Published on: January 21, 2020
Cortical changes in complex regional pain syndrome (CRPS).
C M A Karin Swart1, John F Stins, Peter J Beek
1Research Institute MOVE, Faculty of Human Movement Sciences, VU University Amsterdam, van der Boechorststraat 9, 1081 BT Amsterdam, The Netherlands.
European Journal of Pain (London, England)
|December 23, 2008
Summary
Complex Regional Pain Syndrome (CRPS) involves cortical changes affecting sensory and motor processing. Therapies like mirror therapy show promise for neural restoration, though mechanisms require further study.
Area of Science:
- Neuroscience
- Pain Medicine
- Rehabilitation
Background:
- Complex Regional Pain Syndrome (CRPS) pathophysiology is increasingly linked to alterations in central nervous system structures.
- Cortical changes in CRPS manifest as sensory misperceptions, altered somatosensory maps, and motor cortex dysfunction.
Purpose of the Study:
- To review current research on cortical involvement in CRPS.
- To examine experimental therapeutic interventions targeting sensory-motor cortex dysfunction in CRPS.
Main Methods:
- Systematic review of studies investigating cortical changes in CRPS.
- Analysis of research on mirror therapy and motor imagery for CRPS treatment.
Main Results:
- Evidence supports significant cortical reorganization in CRPS patients, including tactile allodynia and altered body representation.
- Experimental treatments like mirror therapy and motor imagery demonstrate potential for improving neural processing and clinical outcomes.
Conclusions:
- Cortical dysfunction is a key component of CRPS pathophysiology.
- Interventions aimed at cortical plasticity offer a promising avenue for CRPS management, warranting further investigation into underlying neural mechanisms.
![Autoradiographic Measurements of [14C]-Iodoantipyrine in Rat Brain Following Central Post-Stroke Pain](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F53947.jpg&w=3840&q=50)
Related Concept Videos
01:21Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation
Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
01:33Somatosensation
The somatosensory system relays sensory information from the skin, mucous membranes, limbs, and joints. Somatosensation is more familiarly known as the sense of touch. A typical somatosensory pathway includes three types of long neurons: primary, secondary, and tertiary. Primary neurons have cell bodies located near the spinal cord in groups of neurons called dorsal root ganglia. The sensory neurons of ganglia innervate designated areas of skin called dermatomes.