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Updated: Jun 26, 2026
04:48
Chemotherapy-induced Vascular Toxicity - Real-time In vivo Imaging of Vessel Impairment
Published on: January 7, 2015
Potential chemotherapy side effects: what do oncologists tell parents?
Lisa Ysela Ramirez1, Samantha E Huestis, Tsiao Yi Yap
1Department of Psychology, Case Western Reserve University, Cleveland, Ohio, USA.
Pediatric Blood & Cancer
|December 23, 2008
Summary
In acute leukemia informed consent conferences (ICCs), short-term side effects are frequently discussed, while late effects are significantly underrepresented. This imbalance may impact parental understanding of treatment risks.
Area of Science:
- Pediatric Oncology
- Clinical Communication
- Informed Consent
Background:
- Informed consent conferences (ICCs) are crucial for discussing treatment risks with parents of children diagnosed with acute leukemia.
- Understanding the balance of short-term versus late side effects discussed during ICCs is essential for effective communication.
Purpose of the Study:
- To quantify the number and ratio of short-term and late side effects discussed during ICCs for childhood acute leukemia.
- To analyze factors influencing the discussion of side effects in ICCs.
Main Methods:
- Audio-recording and coding of ICCs from 140 childhood leukemia trials across six study sites.
- Analysis of coded side effects, correlating discussion frequency with ICC duration and demographic factors.
Main Results:
- A total of 3,173 acute side effects and 242 late effects were identified across 140 ICCs.
- The mean number of total side effects per ICC was 24, with acute effects significantly outnumbering late effects.
- Longer ICC duration correlated with more side effects discussed; no demographic independence was found.
Conclusions:
- Acute side effects are commonly discussed in initial ICCs, but late effects receive less frequent attention.
- Optimizing the communication ratio of acute to late effects in ICCs may improve parental comprehension of clinically relevant side effects.
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