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Updated: Jun 26, 2026
03:54
A New Ex Vivo Model for the Evaluation of Endoscopic Submucosal Injection Material Performance
Published on: October 19, 2018
Submucosal saline-epinephrine injection in colon polypectomy: appropriate indication
Sang Hyub Lee1, Kyoung Soo Lee, Young Soo Park
1Department of Internal Medicine, Seoul National University Bundang Hospital.
Hepato-Gastroenterology
|December 24, 2008
Summary
Submucosal saline-epinephrine injection is recommended for sessile or large colonic polyps (>8mm) to prevent bleeding. Optional use may be considered for other polyp types to reduce postpolypectomy hemorrhage risk.
Area of Science:
- Gastroenterology
- Endoscopic Procedures
- Colorectal Cancer Prevention
Background:
- Indications for submucosal saline-epinephrine injection after colonic snare polypectomy are debated.
- Varied endoscopist opinions necessitate clarification on optimal usage for preventing postpolypectomy complications.
Purpose of the Study:
- To determine appropriate indications for submucosal saline-epinephrine injection.
- To identify factors influencing postpolypectomy complications like hemorrhage and perforation.
Main Methods:
- Retrospective analysis of 1039 colonic polypectomies in 563 patients.
- Evaluation of clinical and polyp characteristics, including submucosal injection use.
- Statistical analysis of postpolypectomy hemorrhage and perforation rates.
Main Results:
- Hemorrhage occurred in 2.6% and perforation in 0.2% of cases.
- Malignant adenoma, rectal location, and lack of injection increased hemorrhage risk.
- Injection significantly reduced hemorrhage risk in sessile polyps and those >8mm (OR 16.41).
Conclusions:
- Submucosal saline-epinephrine injection is indicated for sessile polyps and those >8mm.
- Optional injection may be considered for other polyp types to prevent postpolypectomy hemorrhage.
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