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[Relationship between acute pancreatitis and systemic inflammation response syndrome in children]

Na Li1, Xiao-Yin Wang

  • 1Department of Pediatrics, Shengjing Hospital, China Medical University, Shenyang 110004, China.

Zhongguo Dang Dai Er Ke Za Zhi = Chinese Journal of Contemporary Pediatrics
|December 24, 2008
PubMed

Insights

Children with acute pancreatitis and systemic inflammatory response syndrome (SIRS) often present with severe pain and fever. Elevated C-reactive protein (CRP) and low calcium levels indicate severity.

Area of Science:

  • Pediatric Gastroenterology
  • Critical Care Medicine
  • Biochemistry

Context:

  • Acute pancreatitis in children is a serious condition.
  • Systemic inflammatory response syndrome (SIRS) can complicate acute pancreatitis, increasing morbidity.
  • Understanding the clinical and biochemical markers of SIRS in pediatric acute pancreatitis is crucial for timely intervention.

Purpose:

  • To investigate the clinical characteristics of pediatric acute pancreatitis associated with SIRS.
  • To identify key biochemical and imaging markers for assessing the severity of acute pancreatitis in children with SIRS.

Summary:

  • Retrospective study of 71 children with acute pancreatitis, comparing those with (n=30) and without (n=41) SIRS.
  • SIRS group exhibited more severe abdominal pain, higher fever, significantly elevated C-reactive protein (CRP), and lower calcium levels.
  • Higher CRP levels and more severe imaging findings correlated with increased SIRS criteria, indicating greater disease severity.

Impact:

  • Identifies severe abdominal pain and fever as key clinical indicators of SIRS in pediatric acute pancreatitis.
  • Highlights serum CRP and calcium levels, along with imaging, as vital for evaluating pancreatitis severity.
  • Suggests a CRP level > 110 mg/L or meeting >3 SIRS criteria predicts high risk for severe acute pancreatitis in children.
Abstract

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