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Published on: January 28, 2020
[Association between plasma macrophage migration inhibitory factor concentration and coronary artery lesion
Li-Xia Yang1, Rui-Wei Guo, Feng Qi
1Department of Cardiology, Kunming General Hospital of Chengdu Military Area, Kunming 650032, China.
Insights
Plasma levels of macrophage migration inhibitory factor (MIF), activator protein-1 (AP-1), and MMP-9 correlate with coronary artery disease severity. Higher concentrations in acute coronary syndrome patients suggest increased plaque instability.
Area of Science:
- Cardiovascular Biology
- Molecular Medicine
- Biochemistry
Background:
- Coronary heart disease (CHD) involves complex inflammatory processes.
- Macrophage migration inhibitory factor (MIF), activator protein-1 (AP-1), and MMP-9 are implicated in inflammatory responses and tissue remodeling.
- Understanding their role in CHD severity is crucial for risk stratification.
Purpose of the Study:
- To investigate the association between plasma MIF, AP-1, and MMP-9 levels and the severity of coronary artery lesions in CHD patients.
- To compare these marker concentrations across different CHD patient groups (stable angina vs. acute coronary syndrome).
Main Methods:
- Plasma concentrations of MIF, AP-1, and MMP-9 were measured using enzyme-linked immunosorbent assay.
- Patients were categorized into normal controls, stable angina pectoris (SAP), and acute coronary syndrome (ACS) groups.
- Coronary artery lesion severity was quantified using the Gensini coronary score based on coronary angiography.
Main Results:
- Plasma MIF, AP-1, and MMP-9 levels were significantly elevated in CHD patients compared to controls.
- Concentrations of these markers were higher in ACS patients than in SAP patients.
- Significant positive correlations were observed between MIF, AP-1, MMP-9 levels and the Gensini coronary score, indicating a link to lesion severity.
Conclusions:
- Plasma MIF, AP-1, and MMP-9 concentrations are positively correlated with the severity of coronary artery lesions in CHD.
- Elevated levels of these markers in ACS patients may indicate greater plaque instability compared to SAP patients.
Objective:
To investigate the relationship between the plasma macrophage migration inhibitory factor (MIF), activator protein-1 (AP-1) and MMP-9 concentrations and the severity of coronary artery lesions in coronary heart disease (CHD) patients.
Methods:
Patients were divided into normal controls (n = 35), stable angina pectoris (SAP, n = 32) and acute coronary syndrome (ACS, n = 75) according to the coronary angiography (CAG), clinical and laboratory examinations. The CAG severity and extent of coronary lesions were analyzed by means of Gensini coronary score system. Enzyme linked immunosorent assay was used to measure the plasma MIF, AP-1 and MMP-9 concentrations.
Results:
Plasma MIF, AP-1 and MMP-9 concentrations were significant increased in CHD patients [MIF: (14.97 +/- 2.11) microg/L, AP-1: 1.43 +/- 0.33, MMP-9: (1.48 +/- 0.14) microg/L] compared to those in control group [MIF: (9.07 +/- 1.28) microg/L, AP-1: 0.71 +/- 0.13, MMP-9: (1.01 +/- 0.07) microg/L, all P < 0.05]. The MIF, AP-1 and MMP-9 concentrations in ACS group [MIF: (16.66 +/- 2.56) microg/L, AP-1: 1.56 +/- 0.22, MMP-9: (1.58 +/- 0.14) microg/L] were also significant higher than those in SAP group [MIF: (11.01 +/- 2.12) microg/L, AP-1: 1.04 +/- 0.25, MMP-9: (1.25 +/- 0.07) microg/L, all P < 0.05] and there was significant positive correlation between MIF, AP-1 and MMP-9 concentrations and the Gensini score of coronary artery lesions (all P < 0.05). AP-1 was positively correlated with MMP-9 in CHD patients (P < 0.05).
Conclusions:
Plasma MIF, AP-1 and MMP-9 concentrations were positively correlated to the severity of coronary lesions in CHD patients. Higher MIF, AP-1 and MMP-9 concentrations in ACS patients than in SAP patients might suggest higher plaque instability in ACS patients.
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