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Related Experiment Video

Updated: Jun 26, 2026

Postconditioning with Lactate-enriched Blood for Cardioprotection in ST-segment Elevation Myocardial Infarction

Postconditioning with Lactate-enriched Blood for Cardioprotection in ST-segment Elevation Myocardial Infarction

Published on: May 28, 2019

Ischaemic postconditioning: from bench to bedside ...

Derick van Vuuren¹, Amanda Lochner

¹Department of Biomedical Sciences, Division of Medical Physiology, Faculty of Health Sciences, University of Stellenbosch, South Africa. dvvuuren@sun.ac.za

Cardiovascular Journal of Africa

|December 24, 2008

Summary

Postconditioning (postC) offers a promising cardioprotective strategy by applying brief reperfusion/ischaemia cycles at reperfusion onset. This approach shows potential for clinical translation in managing myocardial infarction.

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Published on: May 28, 2019

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Experimental Models to Study the Neuroprotection of Acidic Postconditioning Against Cerebral Ischemia

Experimental Models to Study the Neuroprotection of Acidic Postconditioning Against Cerebral Ischemia

Published on: July 31, 2017

Area of Science:

Cardiovascular Medicine
Cardiac Surgery
Ischemic Heart Disease Research

Background:

Rising incidence of ischemic heart disease and acute myocardial infarction (AMI) globally necessitates novel cardioprotective interventions.
Ischemic preconditioning (IPC) shows protective capacity but is limited by its requirement before sustained ischemia.
Postconditioning (postC), applied at reperfusion onset, presents a clinically relevant therapeutic window.

Purpose of the Study:

To evaluate the reliability and potency of postconditioning (postC) in eliciting cardioprotection.
To assess the clinical translatability of postC from laboratory findings to therapeutic application.
To review experimental setups, algorithms, and outcomes of postC in various animal models.

Main Methods:

Review of experimental studies utilizing postconditioning (postC) in animal models (dog, rabbit, mouse, rat, pig).
Analysis of different postC algorithms and their associated cardioprotective outcomes.
Inclusion of preliminary human studies on the efficacy and feasibility of both ischemic and pharmacological postC.

Main Results:

Postconditioning (postC) has demonstrated cardioprotective effects across multiple animal models.
Variations in postC protocols influence the degree of myocardial salvage achieved.
Preliminary human data suggest feasibility and potential efficacy of postC interventions.

Conclusions:

Postconditioning (postC) emerges as a viable strategy for myocardial salvage, complementing standard reperfusion therapies.
Further clinical investigation is warranted to establish robust therapeutic protocols for postC in humans.
The findings support the translation of postC from experimental settings to clinical practice for treating acute myocardial infarction.