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Related Concept Videos

Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...

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Related Experiment Video

Updated: Jun 26, 2026

Injection of Syngeneic Murine Melanoma Cells to Determine Their Metastatic Potential in the Lungs
07:31

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Published on: May 24, 2016

Cutaneous metastases from internal cancers.

R Benmously1, A Souissi, T Badri

  • 1Habib Thameur Dermatology Department, 8 Ali Ben Ayed Street, 1008 Montfleury, Tunis, Tunisia. rym.benmously@rns.tn

Acta Dermatovenerologica Alpina, Pannonica, Et Adriatica
|December 24, 2008
PubMed
Summary
This summary is machine-generated.

Cutaneous metastases (CMs) are rare but can be the first sign of internal cancer. This study analyzed 14 cases, finding lung and breast cancers were primary culprits.

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Area of Science:

  • Dermatology
  • Oncology
  • Pathology

Background:

  • Cutaneous metastases (CMs) from internal malignancies are uncommon and often represent late-stage disease.
  • This report details CM cases from internal tumors observed at a dermatological center in Tunis.

Purpose of the Study:

  • To report and analyze the clinical characteristics and outcomes of cutaneous metastases from internal malignancies.
  • To investigate the diagnostic significance of CMs as an early indicator of underlying cancer.

Main Methods:

  • A retrospective review of clinical records and histological data was conducted.
  • The study encompassed a 14-year period, analyzing all confirmed cases of CMs from internal malignancies.

Main Results:

  • Fourteen cases of CMs were identified (8 males, 6 females) with a mean age of 63.5 (males) and 76.5 (females).
  • CMs were the initial sign of internal malignancy in 64% of patients, typically presenting as firm nodules (93%).
  • Primary cancers included lung (38% in males) and breast (33% in females); common sites were thorax (50%) and abdomen (29%).

Conclusions:

  • Cutaneous metastases are infrequent but can serve as a crucial presenting sign of internal cancers.
  • Early recognition of CMs is vital for timely diagnosis and management of underlying malignancies.