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Updated: Jun 26, 2026

A Pacing-Controlled Procedure for the Assessment of Heart Rate-Dependent Diastolic Functions in Murine Heart Failure Models
Published on: July 21, 2023
Heart rate turbulence in patients with chronic heart failure
Ewa Trzos1, Maria Krzemińska-Pakuła, Tomasz Rechciński
12nd Chair and Department of Cardiology, Medical University, Bieganski Hospital, Lodz, Poland. ewa_trzos@op.pl
Insights
Heart rate turbulence (HRT) parameters, specifically turbulence slope (TS), are often abnormal in patients with chronic heart failure (CHF). An abnormal TS and ventricular tachycardia (VT) predict a higher risk of cardiac events in CHF patients.
Area of Science:
- Cardiology
- Clinical Electrophysiology
- Heart Failure Management
Background:
- Heart rate turbulence (HRT) is a known prognostic marker post-myocardial infarction.
- Its predictive value in chronic heart failure (CHF) remains less established.
- This study investigates HRT's role in CHF prognosis.
Purpose of the Study:
- To evaluate heart rate turbulence (HRT) in patients with chronic heart failure (CHF).
- To determine the prognostic significance of HRT parameters in this patient group.
Main Methods:
- 82 patients with CHF and LVEF <35% underwent 24-hour Holter monitoring.
- Heart rate variability (HRV) and HRT parameters, including turbulence slope (TS) and turbulence onset (TO), were assessed.
- Clinical course and survival were analyzed over a two-year follow-up.
Main Results:
- HRT parameters were frequently abnormal in CHF patients.
- Abnormal turbulence slope (TS <2.5 m/s) and non-sustained ventricular tachycardia (VT) were significant predictors of adverse cardiac events.
- Significant correlations were found between HRV and HRT parameters.
Conclusions:
- Heart rate turbulence (HRT) parameters are often abnormal in patients with chronic heart failure (CHF).
- An abnormal turbulence slope (TS) and episodes of ventricular tachycardia (VT) are significantly associated with an increased risk of cardiac complications in CHF.
Background:
Heart rate turbulence (HRT) has been shown to predict the prognosis after myocardial infarction (MI), but its prognostic value in patients with chronic heart failure (CHF) has not yet been well established.
Aim:
To evaluate HRT in patients with CHF and assess the prognostic significance of HRT in this group.
Methods:
The study group consisted of 82 patients with CHF and left ventricular ejection fraction (LVEF) <35%. All the patients underwent 24-hour Holter monitoring (HM). The heart rate variability (HRV) and HRT parameters were assessed using HRT view software. Two HRT parameters - turbulence slope (TS) and turbulence onset (TO), were calculated. We analysed the clinical course and survival during a two-year follow-up (mean 25+/-9 months).
Results:
The patients were divided into three groups according to the HRT parameters. Group 1 (23 patients) with both normal TO and TS (TO <0%, TS >2.5 m/s), group 2 (30 patients) with abnormal TO or TS, group 3 (29 patients) with abnormal TO and TS (TO >0% and TS <2.5 m/s). Patients from group 1 was significantly younger. There were no differences between patients in aetiology, treatment and the frequency of ventricular premature beats. Significant correlations between HRV and HRT parameters were observed. The correlation was the strongest between TS and SDNN and LF. During the follow-up 9 patients died and 15 were hospitalised for non-fatal infarction or worsening of CHF. Using a multivariate logistic regression model, it was shown that TS <2.5 ms/RR interval, and non-sustained ventricular tachycardia (VT) significantly increased the risk of a serious cardiac events in CHF patients.
Conclusion:
HRT parameters are often abnormal in patients with CHF. An abnormal turbulence slope (TS) and VT episodes are significantly associated with increased risk of cardiac complications in CHF.
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