Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

T-cell differentiation is influenced by thymic microenvironments.

W van Ewijk1

  • 1Department of Immunology, Erasumus University, Rotterdam, The Netherlands.

Annual Review of Immunology
|January 1, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cortical and medullary phenotypes within a mouse thymic epithelial cell line.

In vitro cellular & developmental biology. Animal·2016
Same author

[Emergency psychiatry in Amsterdam: a historical case study].

Tijdschrift voor psychiatrie·2008
Same author

Stat3 in thymic epithelial cells is essential for postnatal maintenance of thymic architecture and thymocyte survival.

Immunity·2001
Same author

Developing thymocytes organize thymic microenvironments.

Current topics in microbiology and immunology·2000
Same author

Stepwise development of thymic microenvironments in vivo is regulated by thymocyte subsets.

Development (Cambridge, England)·2000
Same author

Splenic dendritic cells from the non-obese diabetic mouse induce a prolonged proliferation of syngeneic T cells. A role for an impaired apoptosis of NOD T cells?

Journal of autoimmunity·1999
Same journal

The Neuroimmune Circuitry of Peripheral Sensory Neuron Subtypes in Chronic Pain.

Annual review of immunology·2026
Same journal

The Spectrum of Fibroblast Immune Biology.

Annual review of immunology·2026
Same journal

The Molecular Logic of Immunoglobulin Heavy Chain Class Switch Recombination.

Annual review of immunology·2026
Same journal

Decoding Human T Cell Immunity with Artificial Intelligence and Single-Cell Genomics.

Annual review of immunology·2026
Same journal

Immune Niches in Cancer.

Annual review of immunology·2026
Same journal

T Cell Receptor Signaling and Immune Tolerance: From Autoimmunity to Cancer Immunity.

Annual review of immunology·2026
See all related articles

The thymus microenvironment supports T-cell development through intricate lympho-stromal interactions. Understanding these thymic microenvironments is crucial for insights into T-cell differentiation and immune system function.

Area of Science:

  • Immunology
  • Developmental Biology
  • Cell Biology

Background:

  • Intrathymic T-cell differentiation depends on the complex interplay between developing T cells and their surrounding thymic microenvironments.
  • Thymic microenvironments provide essential signals for T-cell maturation, selection, and repertoire formation.

Purpose of the Study:

  • To review the architecture, phenotype, and function of thymic microenvironments in T-cell differentiation.
  • To discuss experimental strategies for manipulating thymic microenvironments in vitro and in vivo.
  • To explore the role of thymic microenvironments in T-cell selection and the reciprocal influence of T cells on microenvironment development.

Main Methods:

  • Review of existing literature on thymic microenvironment structure and function.

Related Experiment Videos

  • Discussion of experimental approaches using monoclonal antibodies for cell surface targeting.
  • Consideration of novel experimental mouse models for studying thymic microenvironment dynamics.

    • Main Results:

    • Detailed description of thymic microenvironment architecture and stromal cell phenotypes.
    • Elucidation of the supportive role of thymic microenvironments in T-cell differentiation and selection processes.
    • Highlighting the bidirectional communication between T cells and thymic stromal cells.

    Conclusions:

    • Thymic microenvironments are critical for orchestrating T-cell development and immune tolerance.
    • Experimental manipulation and advanced mouse models offer powerful tools to dissect lympho-stromal interactions within the thymus.
    • Further research into thymic microenvironments will advance our understanding of adaptive immunity and autoimmune diseases.