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[Nodular amyloidoma associated with primary pulmonary Malt lymphoma]
M Hourseau1, J Virally, E Habib
1Service d'Anatomie et Cytologie Pathologiques, Hôpital Robert Ballanger, Aulnay sous Bois, France. dropetmur@free.fr
Revue Des Maladies Respiratoires
|December 25, 2008
Summary
Pulmonary amyloidoma, a rare lung mass, can mimic cancer. This case reveals a rare association with Marginal Zone Lymphoma (MALT lymphoma), emphasizing the need for thorough histological examination.
Area of Science:
- Pulmonology
- Oncology
- Hematopathology
Background:
- Pulmonary amyloidoma presents as nodular formations with amyloid deposits, often mimicking lung carcinoma.
- Etiologic diagnosis necessitates investigating underlying conditions like infections, connective tissue disorders, or lymphomas.
Observation:
- A case of an asymptomatic 73-year-old woman with an incidental left upper lobe pulmonary opacity and hilar lymphadenopathy, positive on PET scan.
- Histological examination revealed amyloid deposits surrounded by a dense lymphoid infiltrate.
Findings:
- Immunophenotyping (CD20+, CD5-, CD3-, CD23-) and lambda light chain restriction confirmed pulmonary MALT lymphoma.
- The amyloidosis was characterized as AL lambda type, linked to the MALT lymphoma.
Implications:
- The association of pulmonary amyloidoma and MALT lymphoma is rare and diagnostically challenging due to the amyloid mass obscuring lymphoma.
- Histological search for MALT lymphoma signs, B clonality, and immunoglobulin light chain restriction is crucial for accurate diagnosis in amyloidoma cases.
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