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Updated: Jun 26, 2026

A Murine Model of Ischemic Retinal Injury Induced by Transient Bilateral Common Carotid Artery Occlusion
Published on: November 12, 2020
[Brain hypoperfusion revealed by an ocular ischemic syndrome]
J Hanhart1, P Koskas, M Obadia
1Service d'Ophtalmologie, Fondation Ophtalmologique A. de Rothschild, Paris.
Insights
A 59-year-old female experienced ocular ischemic syndrome due to internal carotid artery occlusion. Treatment involved managing blood pressure, and initiating statin and antiplatelet medications.
Area of Science:
- Ophthalmology
- Neurology
- Vascular Medicine
Background:
- Ocular ischemic syndrome (OIS) is a severe condition often linked to cerebrovascular disease.
- Internal carotid artery (ICA) occlusion is a significant risk factor for stroke and OIS.
Observation:
- A 59-year-old female presented with symptoms consistent with OIS.
- Magnetic Resonance Imaging (MRI) revealed evidence of multiple prior cerebrovascular accidents (strokes).
- The patient had a confirmed occlusion of the internal carotid artery.
Findings:
- The patient's OIS was attributed to the internal carotid artery occlusion.
- Cerebral perfusion pressure management was a key therapeutic goal.
- Treatment included cessation of antihypertensive medication, statin therapy, and antiplatelet agents.
Implications:
- This case highlights the critical link between carotid artery disease and ocular ischemic events.
- Management strategies focus on hemodynamic stability and secondary stroke prevention.
- Aggressive lipid-lowering and antiplatelet therapy are crucial in managing OIS secondary to carotid occlusion.
Abstract:
We report the case of a 59-year-old female presenting an ocular ischemic syndrome caused by occlusion of the internal carotid artery. MRI showed multiple previous episodes of stroke. Therapy consisted in stopping the antihypertensive medication in order to stabilize the residual cerebral perfusion pressure and initiating statin and antiaggregant therapy.
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