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Updated: Jun 26, 2026
05:20
A Murine Model of Ischemic Retinal Injury Induced by Transient Bilateral Common Carotid Artery Occlusion
Published on: November 12, 2020
[Brain hypoperfusion revealed by an ocular ischemic syndrome]
J Hanhart1, P Koskas, M Obadia
1Service d'Ophtalmologie, Fondation Ophtalmologique A. de Rothschild, Paris.
Journal Francais D'Ophtalmologie
|December 25, 2008
Summary
A 59-year-old female experienced ocular ischemic syndrome due to internal carotid artery occlusion. Treatment involved managing blood pressure, and initiating statin and antiplatelet medications.
Area of Science:
- Ophthalmology
- Neurology
- Vascular Medicine
Background:
- Ocular ischemic syndrome (OIS) is a severe condition often linked to cerebrovascular disease.
- Internal carotid artery (ICA) occlusion is a significant risk factor for stroke and OIS.
Observation:
- A 59-year-old female presented with symptoms consistent with OIS.
- Magnetic Resonance Imaging (MRI) revealed evidence of multiple prior cerebrovascular accidents (strokes).
- The patient had a confirmed occlusion of the internal carotid artery.
Findings:
- The patient's OIS was attributed to the internal carotid artery occlusion.
- Cerebral perfusion pressure management was a key therapeutic goal.
- Treatment included cessation of antihypertensive medication, statin therapy, and antiplatelet agents.
Implications:
- This case highlights the critical link between carotid artery disease and ocular ischemic events.
- Management strategies focus on hemodynamic stability and secondary stroke prevention.
- Aggressive lipid-lowering and antiplatelet therapy are crucial in managing OIS secondary to carotid occlusion.
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