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Updated: Jun 26, 2026
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Full-Field Optical Coherence Microscopy for Histology-Like Analysis of Stromal Features in Corneal Grafts
Published on: October 21, 2022
[Deep lamellar anterior keratoplasty]
1Service d'Ophtalmologie, Hôpital Purpan, CHU, Toulouse. arne.jl@chu-toulouse.fr
Journal Francais D'Ophtalmologie
|December 25, 2008
Summary
Penetrating keratoplasty is common but risks rejection. Lamellar keratoplasty, once difficult, now offers better outcomes for stromal diseases due to surgical advances.
Area of Science:
- Ophthalmology
- Corneal Surgery
- Transplantation Immunology
Context:
- Penetrating keratoplasty (PKP) is the standard corneal graft procedure.
- PKP involves full-thickness corneal replacement, risking rejection even for anterior-only diseases.
- Lamellar keratoplasty (LK) was an earlier technique but faced challenges.
Purpose:
- To evaluate the resurgence of lamellar keratoplasty.
- To highlight advancements addressing technical difficulties in LK.
- To position LK as a preferred treatment for stromal corneal diseases.
Summary:
- LK involves partial-thickness corneal transplantation, preserving host endothelium.
- Surgical innovations have improved lamellar dissection accuracy and visual outcomes.
- These advances make LK a viable and potentially superior alternative to PKP for stromal conditions.
Impact:
- Reduced risk of immunologic rejection compared to PKP.
- Improved visual acuity and faster visual rehabilitation for patients.
- Shift in treatment paradigms for corneal stromal diseases, favoring LK.
