Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: Jun 26, 2026

Phosphopeptide Enrichment Coupled with Label-free Quantitative Mass Spectrometry to Investigate the Phosphoproteome in Prostate Cancer

Phosphopeptide Enrichment Coupled with Label-free Quantitative Mass Spectrometry to Investigate the Phosphoproteome in Prostate Cancer

Published on: August 2, 2018

Prostatic acid phosphatase in breast cyst fluid.

Hakan Erbas¹, Oya Erten, Mehmet Emin Irfanoglu

¹Department of Biochemistry, Faculty of Medicine, University of Trakya, Edirne, Turkey. herbas@mail.trakya.edu.tr

The Malaysian Journal of Pathology

|December 26, 2008

Summary

Prostate Acid Phosphatase (PAP) was detected in breast cyst fluid (BCF), suggesting a potential role in breast cancer development. Further research is needed to explore PAP's involvement in transforming growth factor beta (TGF-beta) activation.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Evaluation of Glucose Metabolism and Cardiovascular Risk Factors in Prepubertal Girls with Premature Pubarche

Journal of clinical research in pediatric endocrinology·2022

Same author

Balkan Medical Journal and Legal Regulation

Balkan medical journal·2019

Same author

Three-Dimensional Imaging in Orthodontics.

Turkish journal of orthodontics·2018

Same author

Asymmetric dimethylarginine in experimental breast cancer; action of Vitamin C and E.

JPMA. The Journal of the Pakistan Medical Association·2015

Same author

Effect of rosuvastatin on arginase enzyme activity and polyamine production in experimental breast cancer.

Balkan medical journal·2015

Same author

The Protective Effect of Curcumin on Ionizing Radiation-induced Cataractogenesis in Rats.

Balkan medical journal·2014

Area of Science:

Oncology
Biochemistry

Background:

Gross cystic breast disease is a common benign breast condition associated with an increased risk of breast cancer.
Apocrine breast cysts may confer a higher risk of breast cancer compared to cysts lined by flattened epithelium.
Transforming growth factor beta (TGF-beta) exhibits growth-inhibitory effects on epithelial cells, suggesting a protective role in cancer, but requires activation from its latent form.

Purpose of the Study:

To investigate the presence of Prostatic Acid Phosphatase (PAP) in breast cyst fluid (BCF).
To explore the potential role of PAP in breast cancer development, possibly through TGF-beta activation, similar to Prostate Specific Antigen (PSA).

Main Methods:

Detection of PAP in two groups of BCF samples using an Enzyme-Linked Immunosorbent Assay (ELISA) kit.

More Related Videos

Isolation of Proximal Fluids to Investigate the Tumor Microenvironment of Pancreatic Adenocarcinoma

Isolation of Proximal Fluids to Investigate the Tumor Microenvironment of Pancreatic Adenocarcinoma

Published on: November 5, 2020

Modeling Breast Cancer in Human Breast Tissue using a Microphysiological System

Modeling Breast Cancer in Human Breast Tissue using a Microphysiological System

Published on: April 23, 2021

Related Experiment Videos

Last Updated: Jun 26, 2026

Phosphopeptide Enrichment Coupled with Label-free Quantitative Mass Spectrometry to Investigate the Phosphoproteome in Prostate Cancer

Phosphopeptide Enrichment Coupled with Label-free Quantitative Mass Spectrometry to Investigate the Phosphoproteome in Prostate Cancer

Published on: August 2, 2018

Isolation of Proximal Fluids to Investigate the Tumor Microenvironment of Pancreatic Adenocarcinoma

Isolation of Proximal Fluids to Investigate the Tumor Microenvironment of Pancreatic Adenocarcinoma

Published on: November 5, 2020

Modeling Breast Cancer in Human Breast Tissue using a Microphysiological System

Modeling Breast Cancer in Human Breast Tissue using a Microphysiological System

Published on: April 23, 2021

Main Results:

Prostatic Acid Phosphatase (PAP) was found in breast cyst fluid (BCF).
No statistically significant difference in PAP levels was observed between the two studied cyst groups.

Conclusions:

The presence of PAP in BCF indicates a potential involvement in the development of breast cancer from cystic breast diseases.
Further investigation is required to elucidate the role of PAP in TGF-beta activation and its implications in breast cancer pathogenesis.