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Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer
Published on: November 2, 2013
Prostate-specific antigen in breast disease
Bee Hoon Poh1, Gita Jayaram, Pavai Sthaneshwar
1Department of Pathology, Faculty of Medicine, University Malaya Medical Centre, Kuala Lumpur, Malaysia. pohbh73@hotmail.com
The Malaysian Journal of Pathology
|December 26, 2008
Summary
This preliminary study found no significant difference in tissue prostate-specific antigen (PSA) between benign and malignant breast lesions. Detectable serum PSA levels were too low for analysis, suggesting further research is needed on PSA
Area of Science:
- Oncology
- Biochemistry
Background:
- Prostate-specific antigen (PSA) is a known biomarker for prostate cancer.
- Its role in breast lesions remains largely unexplored.
- Understanding potential biomarkers can aid in breast cancer diagnosis and prognosis.
Purpose of the Study:
- To evaluate tissue and serum prostate-specific antigen (PSA) in breast lesions.
- To compare tissue PSA expression in benign versus malignant breast tissues.
- To correlate tissue PSA with established prognostic factors in breast carcinoma.
Main Methods:
- Tissue PSA immunoreactivity was assessed in women with breast carcinoma and benign breast lesions.
- Tissue PSA was compared with prognostic indicators (tumor size, nodal status, histology, receptor status, c-erbB-2).
- Serum free PSA levels were measured pre- and post-operatively to correlate with tissue PSA.
Main Results:
- Tissue PSA immunoreactivity was observed in 40% of malignant and 43% of benign lesions.
- No significant difference in tissue PSA was found between benign and malignant groups or with prognostic indicators.
- Serum PSA levels were below detection limits in most cases, precluding statistical analysis.
Conclusions:
- This preliminary study found no significant association between tissue PSA expression and breast lesion type or prognostic markers.
- Low detectable serum PSA levels limited statistical evaluation.
- Further research is warranted to investigate the potential role of PSA in breast disease.
