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Related Concept Videos

Non-Canonical Wnt Signaling Pathways01:41

Non-Canonical Wnt Signaling Pathways

Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
Non-Canonical Wnt Signaling Pathways01:41

Non-Canonical Wnt Signaling Pathways

Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
Canonical Wnt Signaling Pathway02:54

Canonical Wnt Signaling Pathway

The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which results in tumor...
Canonical Wnt Signaling Pathway02:54

Canonical Wnt Signaling Pathway

The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which results in tumor...
Zygotic Development And Stem Cell Formation01:10

Zygotic Development And Stem Cell Formation

The development of all multicellular organisms starts with the fusion of haploid cells called sperm and egg to form a diploid zygote. A zygote is a totipotent cell that can develop into a complete organism. The zygote undergoes cell division or cleavage to form an 8-cell mass. Until this stage, the cells are spherical, loosely attached, and remain totipotent. Totipotent cells are capable of developing both the embryonic and the extraembryonic tissues. However, as they continue to divide, they...
Notch Signaling Pathway03:14

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...

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Updated: Jun 26, 2026

Modeling Paracrine Noncanonical Wnt Signaling In Vitro
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Modeling Paracrine Noncanonical Wnt Signaling In Vitro

Published on: December 10, 2021

Dictyostelium development: a prototypic Wnt pathway?

Adrian J Harwood1

  • 1Cardiff School of Biosciences, Cardiff University, Cardiff, Wales, UK.

Methods in Molecular Biology (Clifton, N.J.)
|December 26, 2008
PubMed
Summary
This summary is machine-generated.

The evolution of Wnt signaling, crucial in animals, is explored using the social amoeba Dictyostelium discoideum. This organism possesses key Wnt pathway components like GSK-3 and beta-catenin homolog Aardvark (Aar), aiding in development and cell adhesion.

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Using Confocal Analysis of Xenopus laevis to Investigate Modulators of Wnt and Shh Morphogen Gradients
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Using Confocal Analysis of Xenopus laevis to Investigate Modulators of Wnt and Shh Morphogen Gradients

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Last Updated: Jun 26, 2026

Modeling Paracrine Noncanonical Wnt Signaling In Vitro
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The Power of Simplicity: Sea Urchin Embryos as in Vivo Developmental Models for Studying Complex Cell-to-cell Signaling Network Interactions
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Using Confocal Analysis of Xenopus laevis to Investigate Modulators of Wnt and Shh Morphogen Gradients
08:10

Using Confocal Analysis of Xenopus laevis to Investigate Modulators of Wnt and Shh Morphogen Gradients

Published on: December 14, 2015

Area of Science:

  • Evolutionary developmental biology
  • Cellular and molecular biology

Background:

  • Wnt signaling is a fundamental biological pathway in animals.
  • Its evolutionary origins and presence in non-metazoan organisms remain largely unexplored.
  • The social amoeba Dictyostelium discoideum offers a model system to study these ancient pathways.

Purpose of the Study:

  • To investigate the evolutionary history of Wnt signaling components.
  • To elucidate the role of Wnt pathway homologs in Dictyostelium development.
  • To understand the ancient functions of proteins like GSK-3, beta-catenin, and Frizzled.

Main Methods:

  • Genomic analysis of Dictyostelium discoideum.
  • Identification and characterization of Wnt pathway gene homologs.
  • Developmental biology studies in Dictyostelium.

Main Results:

  • Dictyostelium discoideum possesses homologs of key Wnt pathway genes, including GSK-3 and beta-catenin (Aardvark/Aar).
  • Aardvark (Aar) is essential for pattern formation and adherens junction formation during multicellular development.
  • Sixteen Frizzled (Fz) gene homologs were identified in the Dictyostelium genome.

Conclusions:

  • Dictyostelium discoideum serves as a valuable model for studying the evolution of Wnt signaling.
  • Homologs of Wnt pathway components play conserved roles in development and cell adhesion across eukaryotes.
  • The presence of multiple Frizzled homologs suggests complex signaling regulation in early eukaryotes.