Related Experiment Video
Updated: Jun 26, 2026

Cardiac Loading using Passive Left Atrial Pressurization and Passive Afterload for Graft Assessment
Published on: August 2, 2024
Prognostic implications of stress-induced transient ischemic dilation of the left ventricle in patients with systolic
Alberto Bestetti1, Riccardo Bigi, Paolo Terranova
1Nuclear Medicine Unit, Institute of Radiological Sciences, University of Milan School of Medicine, Casa di Cura San Pio X, Via Nava, 31, 20159 Milano, Italy. alberto.bestetti@unimi.it
Purpose:
To verify whether stress-induced transient ischemic dilation (TID) of the left ventricle may help refine prognostic assessment of patients with resting systolic dysfunction and fixed perfusion defects.
Methods:
Two hundred seventy patients with resting ejection fraction
Results:
During a median time of 24 months, 47 events (10 deaths, 20 acute coronary syndromes and 17 revascularization) were observed. After adjusting for clinical and stress testing variables, the unfeasible exercise test [hazard ratio (HR) 1.82, 95% confidence interval (CI) 1.02, 3.24] and the highest quartile of TID ratio [HR 1.93, 95% CI 1.05, 3.54] were the only independent predictors of outcome. The highest quartile of TID ratio was associated to significantly lower percent of event-free survival.
Conclusions:
Left ventricular TID ratio helps refine outcome prediction in patients with resting systolic dysfunction and fixed perfusion defects, thus reducing risk of a false negative result.
Related Concept Videos
Mitral Stenosis I: Introduction
Mitral Regurgitation I: Introduction
Imbalances in Cardiac Output
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send blood...
Heart Failure II: Pathophysiology
