Related Experiment Video
Updated: Jun 26, 2026

Induction of an Isoelectric Brain State to Investigate the Impact of Endogenous Synaptic Activity on Neuronal Excitability In Vivo
Published on: March 31, 2016
Electrical activity of no-producing neuron depends on NO level
1N. K. Kol'tsov Institute of Developmental Biology, Russian Academy of Sciences, Moscow, Russia. dyakonova@nm.ru
Abstract:
NO-producing neuron exhibited an excitatory response to the decrease in NO concentration, which was induced by NO synthase inhibitor N-nitro-L-arginine or specific NO acceptor 2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide. Addition of NO donors to the medium inhibits neuronal activity. The excitatory effects of N-nitro-L-arginine and 2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide were preserved, while the inhibitory action of NO donors significantly decreased after isolation of the neuron. These findings indicate that NO regulates activity of these neurons by the negative feedback mechanism. This regulation includes the following complementary mechanisms: (1) endogenous mechanism of cell self-activation in response to the decrease in NO concentration; and (2) exogenous mechanism of cell-mediated inhibition in response to NO excess.
More Related Videos
Related Concept Videos
Action Potentials
The Role of Ion Channels in Neuronal Computation
Sometimes a single EPSP is strong enough to induce an action potential in the postsynaptic neuron. However, multiple presynaptic inputs must often create EPSPs around the same time for the postsynaptic neuron to be sufficiently depolarized to fire an action potential.
Action Potential
Membrane potential in neurons
Neurons typically have a resting membrane potential of about -70 millivolts (mV). When they receive...
Action Potential
Membrane potential in neurons
Neurons typically have a resting membrane potential of about -70 millivolts (mV). When they receive...
Resting Potential Decay
At rest, the K+ is the main ion that moves across the membrane through...
Resting Potential Decay
At rest, the K+ is the main ion that moves across the membrane through...

