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Related Experiment Video

Updated: Jun 26, 2026

Stem Cell Transplantation in an in vitro Simulated Ischemia/Reperfusion Model

Stem Cell Transplantation in an in vitro Simulated Ischemia/Reperfusion Model

Published on: November 5, 2011

Stem cell transplantation; Iranian experience.

Ardeshir Ghavamzadeh¹, Kamran Alimoghaddam, Kamran Alimogaddam

¹Hematology-Oncology and Stem Cell Transplantation Research Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran. bmtcontact@sina.tums.ac.ir

Archives of Iranian Medicine

|December 30, 2008

Summary

This study analyzed 2042 stem cell transplantations performed between 1991 and 2007. The overall survival rate was 74.9%, with common causes of mortality including relapse and infections.

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Isolation and Transplantation of Hematopoietic Stem Cells (HSCs)

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Stem Cell Transplantation in an in vitro Simulated Ischemia/Reperfusion Model

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Isolation and Transplantation of Hematopoietic Stem Cells (HSCs)

Isolation and Transplantation of Hematopoietic Stem Cells (HSCs)

Published on: February 25, 2007

Area of Science:

Hematology
Oncology
Transplantation Medicine

Background:

Stem cell transplantation is a critical therapeutic modality for various hematologic and oncologic conditions.
The Hematology-Oncology and Stem Cell Transplantation Research Center has accumulated extensive experience since 1991.

Purpose of the Study:

To report the outcomes of a large cohort of stem cell transplantations.
To analyze the survival rates and causes of mortality following stem cell transplantation.

Main Methods:

Retrospective analysis of 2042 stem cell transplantations (allogeneic, autologous, syngeneic) performed from March 1991 to December 2007.
Data collection included patient demographics, disease indications, transplant types, and survival status.
Survival rates and causes of death were analyzed.

Main Results:

A total of 2042 stem cell transplantations were performed for a wide spectrum of hematologic malignancies, solid tumors, and non-malignant diseases.
The overall survival rate at a median follow-up of up to 168 months was 74.9% (1530 patients alive).
The mortality rate was 25.1% (512 patients), with primary causes including relapse, infections, graft-versus-host disease, and hemorrhagic cystitis.

Conclusions:

Stem cell transplantation is an effective treatment with a significant survival benefit for a broad range of diseases.
Continuous monitoring and management of complications like infections and graft-versus-host disease are crucial for improving outcomes.