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[Value of mfVEP test in pituitary tumors diagnosis]
Anna Piekarska1, Wojciech Lubiński, Wojciech Gosławski
1Z Katedry i Kliniki Okulistyki Pomorskiej Akademii Medycznej w Szczecinie. annapiekarska26@interia.pl
Purpose:
To evaluate the mfVEP test in detection of the optic nerve neuropathy in pituitary tumors.
Material And Methods:
We examined 30 eyes of 15 patients with confirmed by MRI pituitary tumors (7 patients with macroadenomas and 8 patients with microadenomas). In all patients the routine ophthalmologic examination, multifocal visual evoked potentials (mfVEP) and standard static perimetry (central 24-2 threshold), were performed. The control group consisted of 30 eyes of 15 healthy persons.
Results:
In 53% (16/30) of eyes manifested changes in static perimetry and/or in mfVEP test. In 13% (4/30) of eyes abnormal static perimetry and mfVEP were simultaneously observed. The only mfVEP abnormalities were the most frequent feature and were observed in 30% (9/30) of eyes. Only abnormal static perimetry results were observed in 10% (3/10) of eyes. In those eyes in related areas of mfVEP recordings the mean peak-to-peak amplitude was significantly reduced compare to the control group. In mfVEP test statistically significant peak-to-peak amplitude reduction was observed in superotemporal quadrants in comparison to the control group (p < 0.009).
Conclusions:
MfVEP can be useful test in the optic nerve dysfunction/ neuropathy diagnosis in patients with pituitary tumors.
Insights
The multifocal visual evoked potential (mfVEP) test is effective in diagnosing optic nerve damage in patients with pituitary tumors, showing abnormalities in 53% of cases. This test aids in detecting optic nerve neuropathy when other methods may not.
Area of Science:
- Ophthalmology
- Neuroscience
Context:
- Pituitary tumors can compress the optic nerve, leading to visual field defects and optic nerve neuropathy.
- Early detection of optic nerve dysfunction is crucial for timely intervention and management of pituitary tumor patients.
Purpose:
- To assess the utility of the multifocal visual evoked potential (mfVEP) test in identifying optic nerve neuropathy associated with pituitary tumors.
Summary:
- A study involving 15 patients with pituitary tumors revealed that mfVEP detected abnormalities in 30% of eyes, often as the sole indicator of optic nerve dysfunction.
- Combined with standard perimetry, mfVEP identified issues in 53% of affected eyes, with significant amplitude reductions noted in superotemporal quadrants compared to controls.
Impact:
- The mfVEP test demonstrates potential as a valuable diagnostic tool for optic nerve dysfunction in the context of pituitary tumors.
- Findings suggest mfVEP can complement existing methods, improving the detection rate of visual pathway compromise in this patient population.
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