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P16 expression in odontogenic tumors
Luciano Artese1, Adriano Piattelli, Corrado Rubini
1Dental School, University of Chieti-Pescara, Chieti, Italy.
Aims And Background:
The aim of the study was to examine the immunohistochemical expression of a cell-cycle-related factor (p16) in order to elucidate its role in the growth and diffusion of odontogenic tumors.
Study Design:
Thirty-six odontogenic tumors were divided into two groups according to their clinical behavior: group A and group B composed of tumors at low and high risk of recurrences, respectively. The ANOVA test was used to detect differences between the two groups.
Results:
p16 was expressed in both groups, but with different localization. A statistically significant difference was found in p16 expression of peripheral cells, with an increase in the expression in group B compared to group A (P < 0.05). In addition, there was no significant difference in p16 positive expression of the central cells of odontogenic tumors, which was high in both groups.
Conclusions:
The present data show a correlation between p16 expression and the biological behavior of odontogenic tumors.
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