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Disseminated intravascular coagulation during treatment with thalidomide. A case report
Davide Tassinari1, Paola Tombesi, Sergio Sartori
1Department of Oncology, City Hospital, Rimini, Italy. dtassinari@rimini.com
Abstract:
The treatment with thalidomide is associated with an increased risk of thromboembolic events, in particular when it is combined with chemotherapy or dexamethasone. However, despite this well-documented prothrombotic effect, to our knowledge disseminated intravascular coagulation has never been reported in hematological or oncological patients treated with thalidomide. We report a case of disseminated intravascular coagulation in a patient treated with thalidomide and dexamethasone for advanced, heavily pretreated hormone-resistant prostate cancer in which a relationship with the treatment appears highly likely.
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