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Intrarenal Injection of Escherichia coli in a Rat Model of Pyelonephritis
Published on: July 18, 2017
Xanthogranulomatous pyelonephritis successfully treated with antibiotics only
Chang-I Ho1, Yao-Ko Wen, Mei-Ling Chen
1Division of Nephrology, Department of Medicine, Changhua Christian Hospital, Changhua, Taiwan, ROC.
Journal of the Chinese Medical Association : JCMA
|December 31, 2008
Summary
A rare case of xanthogranulomatous pyelonephritis in a leukemia patient with splenic abscess was successfully treated with antibiotics. The antibiotic therapy resolved both the splenic abscess and the renal mass.
Area of Science:
- Nephrology
- Infectious Diseases
- Oncology
Background:
- Xanthogranulomatous pyelonephritis (XGP) is a rare, chronic destructive inflammation of the kidney.
- It is often associated with urinary tract obstruction or nephrolithiasis.
- Leukemia is an uncommon comorbidity in patients with XGP.
Observation:
- A 73-year-old female leukemia patient presented with urinary tract infection, splenic abscess, and a renal mass.
- Klebsiella pneumoniae was identified in both urine and splenic abscess cultures.
- Renal mass biopsy confirmed xanthogranulomatous pyelonephritis.
Findings:
- The patient received 2 months of antibiotic therapy due to high surgical risk.
- Antibiotic treatment successfully resolved the splenic abscess.
- Follow-up ultrasonography demonstrated progressive resolution of the renal mass.
Implications:
- This case highlights the potential for successful antibiotic-only treatment of xanthogranulomatous pyelonephritis, even in complex cases involving splenic abscess and leukemia.
- It suggests that conservative management with antibiotics may be a viable option for select patients.
- This report contributes to the understanding of XGP management in immunocompromised patients.
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