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Post-translational modification of lens proteins in cataract
1Nuffield Laboratory of Ophthalmology, Oxford, UK.
Lens and Eye Toxicity Research
|January 1, 1991
Abstract:
Evidence supporting the role of non-enzymic post-translational modification of lens proteins in cataract is reported as presented at a meeting in Bydgoszcz, Poland in August 1990. Glycation and carbamylation have been studied intensively recently. Both produce modified proteins with properties similar to those of 'molten-globule' intermediates of protein folding and unfolding pathways.