Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Growth of Cartilage and Bone Tissue

Growth of Cartilage and Bone Tissue

Chondrocytes form a temporary cartilaginous model by dividing and secreting a thick gel-like extracellular matrix. Once the chondrocytes undergo programmed cell death, osteoblasts enter the site of the cartilaginous model. The process of replacing the temporary cartilaginous model with bone in an ordered manner is called endochondral ossification. In endochondral ossification, not all of the cartilage is replaced by bone tissue. Some cartilage that performs a protective and supportive function...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Polystyrene Nanoplastics Induce Inflammasome Activation in Nasal Epithelial Cells via ROS-Mediated Mitochondrial Dysfunction.

Environmental toxicology·2026

Same author

Clinical predictors of pediatric obstructive sleep apnea: Demographic and physical factors.

International journal of pediatric otorhinolaryngology·2026

Same author

Fractional Exhaled Nitric Oxide for Diagnosing Eosinophilic Chronic Rhinosinusitis: A Systematic Review and Meta-analysis.

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery·2026

Same author

Otolaryngology Applicants' Preferences for Virtual vs In-Person Interviews During the 2023-2024 Application Cycle.

Journal of graduate medical education·2025

Same author

The Prelacrimal Recess Approach: A Review of Surgical Applications, Outcomes, and Recent Advances.

Journal of rhinology : official journal of the Korean Rhinologic Society·2025

Same author

Patients With Giant Facial Basal Cell Carcinoma, Who Are They?-A Psychosocial Profile.

The Laryngoscope·2025

Search research articles

Related Experiment Video

Updated: Jun 26, 2026

Integrated Bone Formation Through In Vivo Endochondral Ossification Using Mesenchymal Stem Cells

Integrated Bone Formation Through In Vivo Endochondral Ossification Using Mesenchymal Stem Cells

Published on: July 14, 2023

Subcutaneous implants coated with tissue-engineered cartilage.

Soo Whan Kim¹, Eric J Dobratz, John A Ballert

¹Department of Otolaryngology-Head and Neck Surgery, Catholic University of Korea College of Medicine, Seoul, Korea.

The Laryngoscope

|January 2, 2009

Summary

Tissue-engineered cartilage (TEC) successfully coated porous high-density polyethylene (PHDPE) and expanded polytetrafluoroethylene (e-PTFE) implants in mice. This method shows promise for improving alloplastic implant performance and integration.

More Related Videos

Biotribological Testing and Analysis of Articular Cartilage Sliding against Metal for Implants

Biotribological Testing and Analysis of Articular Cartilage Sliding against Metal for Implants

Published on: May 14, 2020

Matrix-assisted Autologous Chondrocyte Transplantation for Remodeling and Repair of Chondral Defects in a Rabbit Model

Matrix-assisted Autologous Chondrocyte Transplantation for Remodeling and Repair of Chondral Defects in a Rabbit Model

Published on: May 21, 2013

Related Experiment Videos

Last Updated: Jun 26, 2026

Integrated Bone Formation Through In Vivo Endochondral Ossification Using Mesenchymal Stem Cells

Integrated Bone Formation Through In Vivo Endochondral Ossification Using Mesenchymal Stem Cells

Published on: July 14, 2023

Biotribological Testing and Analysis of Articular Cartilage Sliding against Metal for Implants

Biotribological Testing and Analysis of Articular Cartilage Sliding against Metal for Implants

Published on: May 14, 2020

Matrix-assisted Autologous Chondrocyte Transplantation for Remodeling and Repair of Chondral Defects in a Rabbit Model

Matrix-assisted Autologous Chondrocyte Transplantation for Remodeling and Repair of Chondral Defects in a Rabbit Model

Published on: May 21, 2013

Area of Science:

Biomaterials Science
Tissue Engineering
Orthopedic Surgery

Background:

Alloplastic implants are widely used in reconstructive surgery.
Improving the integration and long-term performance of these implants remains a challenge.
Tissue-engineered cartilage (TEC) offers a potential solution for enhancing implant biocompatibility and function.

Purpose of the Study:

To evaluate the feasibility of coating PHDPE and e-PTFE alloplastic implants with human septal chondrocyte-derived TEC.
To assess the gross, histological, and biochemical characteristics of TEC-coated implants in a mouse model.
To determine the potential of this approach to improve implant integration and shape maintenance.

Main Methods:

PHDPE and e-PTFE disks were coated with alginate-impregnated human septal chondrocytes (experimental group) or alginate alone (control group).
Implants were surgically placed into athymic nude mice.
Specimens were analyzed at 10 and 20 weeks post-implantation for weight, diameter, histology, and biochemical composition.

Main Results:

Successful generation of TEC-coated implants in 94.7% of experimental mice.
Significant maintenance of construct diameter and increase in weight in the TEC group compared to controls.
Histological and biochemical analyses confirmed neocartilage formation with glycosaminoglycan content reaching 80% of native cartilage.
More extensive fibrovascular ingrowth into implant pores was observed in PHDPE compared to e-PTFE implants.

Conclusions:

Reliable production of TEC-coated alloplastic implants is achievable in an athymic nude mouse model.
TEC coating promotes shape maintenance and neocartilage formation within the implant pores.
This integrated approach holds potential for enhanced long-term implant fixation and infection resistance.