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Updated: Jun 26, 2026

Preparation of Oligomeric β-amyloid1-42 and Induction of Synaptic Plasticity Impairment on Hippocampal Slices
04:41

Preparation of Oligomeric β-amyloid1-42 and Induction of Synaptic Plasticity Impairment on Hippocampal Slices

Published on: July 14, 2010

Picomolar amyloid-beta positively modulates synaptic plasticity and memory in hippocampus

Daniela Puzzo1, Lucia Privitera, Elena Leznik

  • 1Department of Pathology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, New York 10032, USA.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
|January 2, 2009
PubMed
Summary

Low concentrations of amyloid-beta (Abeta) enhance memory and synaptic plasticity via nicotinic receptors. High Abeta concentrations, however, impair these functions, highlighting a dual role in brain health and Alzheimer's disease.

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