Sinonasal chondromyxoid fibroma

Area of Science:

• Oncology
• Pathology
• Skeletal Biology

Background:

• Chondromyxoid fibroma (CMF) is a rare, benign cartilaginous tumor typically found in long bones.
• CMF can exceptionally occur in unusual locations, including facial bones and the sinonasal tract.

Observation:

• A case report details a 60-year-old woman with a CMF of the nasal septum.
• Initial imaging suggested a vascular tumor or malignancy.
• Histopathological examination and SOX9 immunostaining confirmed the diagnosis of CMF.

Findings:

• Microscopic analysis revealed typical CMF features.
• SOX9 immunostaining confirmed the cartilaginous origin of the tumor.
• The patient underwent successful surgical excision and remained disease-free at 12 months.

Implications:

• Accurate diagnosis of CMF is crucial, especially in atypical locations, due to its potential misdiagnosis as chondrosarcoma.
• SOX9 immunostaining is a valuable tool for identifying the chondroid nature of CMF.
• This case highlights the importance of considering rare tumors in differential diagnoses for sinonasal lesions.